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    Arrb2 arrestin, beta 2 [ Rattus norvegicus ]

    Gene ID: 25388, updated on 19-May-2012

    Summary

    Official Symbol
    Arrb2provided by RGD
    Official Full Name
    arrestin, beta 2provided by RGD
    Primary source
    RGD:2157
    See related
    Ensembl:ENSRNOG00000019308
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BARRES; MGC105502
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    Location :
    10q24
    Sequence :
    Chromosome: 10; NC_005109.2 (57244071..57284166)
    See Arrb2 in MapViewer

    Chromosome 10 - NC_005109.2Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene mediator complex subunit 11 Neighboring gene chemokine (C-X-C motif) ligand 16 Neighboring gene zinc finger, MYND-type containing 15

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:247426 BioGRID:106663 ADRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:247426 BioGRID:107587 AP2M1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:246366 Adrb2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:107623 CLTC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:248590 Park2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:247426 BioGRID:248372 Ubc    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Homology

    Pathways from BioSystems

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Morphine addiction, organism-specific biosystem (from KEGG)
      Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Morphine addiction, conserved biosystem (from KEGG)
      Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
      Myometrial Relaxation and Contraction Pathways
    • Olfactory transduction, organism-specific biosystem (from KEGG)
      Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Olfactory transduction, conserved biosystem (from KEGG)
      Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
    • Phototransduction, organism-specific biosystem (from KEGG)
      Phototransduction, organism-specific biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
    • Phototransduction, conserved biosystem (from KEGG)
      Phototransduction, conserved biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem
      TGF-beta Receptor Signaling Pathway
    • Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystem (from REACTOME)
      Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    D1 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    alpha-1A adrenergic receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    alpha-1B adrenergic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    follicle-stimulating hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 2A serotonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Not type 2A serotonin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP
    Inferred from Mutant Phenotype
    more info
     
    desensitization of G-protein coupled receptor protein signaling pathway by arrestin ISO
    Inferred from Sequence Orthology
    more info
     
    desensitization of G-protein coupled receptor protein signaling pathway by arrestin TAS
    Traceable Author Statement
    more info
    PubMed 
    detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
     
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    follicle-stimulating hormone signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
     
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cAMP biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cAMP catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-arrestin-2
    Names
    beta-arrestin-2
    arrestin beta-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012911.1NP_037043.1  beta-arrestin-2

      Status: PROVISIONAL

      Source sequence(s)
      M91590
      UniProtKB/Swiss-Prot
      P29067
      Related
      ENSRNOP00000026207, ENSRNOT00000026207
      Conserved Domains (1) summary
      cl02844
      Location:199350
      Blast Score: 302
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: Build 4.2

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly (based on RGSC_v3.4)

    Genomic

    1. NC_005109.2 Reference assembly (based on RGSC_v3.4)

      Range
      57244071..57284166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate assembly (Rn_Celera)

    Genomic

    1. AC_000078.1 Alternate assembly (Rn_Celera)

      Range
      54285120..54301063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AF051457.1 AAC28617.1 Sprague-Dawley
    genomic CH473948.1 EDM05002.1
      EDM05003.1
    mRNA BC087578.1 AAH87578.1
    mRNA M91590.1 AAA74460.1 Sprague-Dawley
    mRNA U03627.1 AAA17551.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29067.1 GenPept UniProtKB/Swiss-Prot:P29067

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