Sstr5 somatostatin receptor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Sstr5provided by RGD
Official Full Name: somatostatin receptor 5provided by RGD
Primary source: RGD:3765
See related: Ensembl:ENSRNOG00000018834
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Smstr5; Somato
Summary: transmembrane receptor for somatostatin 28; coupled to a G-protein which inhibits adenylyl cyclase; may also activate the mitogen-activated protein (MAP) kinase cascade [RGD, Feb 2006]

Genomic context

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Location :: 10q12

Sequence :: Chromosome: 10; NC_005109.3 (14664005..14670083, complement)

See Sstr5 in MapViewer

Chromosome 10 - NC_005109.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Somatostatin inhibited GIP and glucagon-like peptide-1 (GLP-1) secretion from primary small intestinal cultures, in part through SSTR5.
Title: Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.
Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.
Title: Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release.
The combined activation of SSTR1 and -2 shows a partial synergism as far as antiproliferative activity, whereas SSTR2 and -5 activation results in a response resembling the SSTR5 effects.
Title: Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2.
All five SSTR are expressed in splanchnic blood vessels in normal and cirrhotic rats.
Title: Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats.
These results suggest that sst(5) may serve as an autoreceptor or conventional receptor in retinal ACs.
Title: Expression of somatostatin receptor subtype 5 in rat retinal amacrine cells.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystem
GPCRs, Class A Rhodopsin-like
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Peptide GPCRs, organism-specific biosystem (from WikiPathways)
Peptide GPCRs, organism-specific biosystem
Peptide GPCRs
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

G67509 (e-PCR)
- UniSTS:186770

RH94731 (e-PCR)
- UniSTS:119978

Homology

Homologs of the Sstr5 gene: The Sstr5 gene is conserved in human, chimpanzee, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
somatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed
somatostatin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
glucose homeostasis	IEA Inferred from Electronic Annotation more info
glucose homeostasis	ISO Inferred from Sequence Orthology more info
regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
somatostatin signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: somatostatin receptor type 5

Names: somatostatin receptor type 5; SS5R; SS5-R; SS-5-R; Somatostatin receptor subtype 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012882.2 → NP_037014.2 somatostatin receptor type 5

Status: VALIDATED

Source sequence(s)

AABR06063021

UniProtKB/TrEMBL

G3V8G3

Related

ENSRNOP00000025451, ENSRNOT00000025451

Conserved Domains (2) summary

pfam00001
Location:60 – 303
Blast Score: 422

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:45 – 176
Blast Score: 110

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005109.3 Reference Rnor_5.0 Primary Assembly

Range

14664005..14670083, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000078.1 Alternate Rn_Celera

Range

14177783..14183861, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06063021.1 (55365..61443)	None
genomic	AAHX01062928.1 (9105..15183)	None
genomic	CH473948.1	EDM03934.1
		EDM03935.1
mRNA	L04535.1	AAA17029.1	Sprague-Dawley
mRNA	U01152.1	AAC09011.1