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Bglap bone gamma-carboxyglutamate protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 25295, updated on 8-May-2016
Official Symbol
Bglapprovided by RGD
Official Full Name
bone gamma-carboxyglutamate proteinprovided by RGD
Primary source
RGD:2206
See related
Ensembl:ENSRNOG00000019607 Vega:OTTRNOG00000002061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Bgp; Bgpr; Bgpra; Bglap2
Summary
highly conserved protein associated with mineralized bone matrix; protein is secreted by calcified tissues and is regulated by vitamin D3 [RGD, Feb 2006]
Orthologs
Location:
2q34
Exon count:
5
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187741770..187748446, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (207144494..207150926, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene uncharacterized LOC103691618 Neighboring gene polyamine-modulated factor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of bone IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of bone TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
cell aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
ossification IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast development IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to gravity IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydroxyisoflavone IEP
Inferred from Expression Pattern
more info
PubMed 
response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
response to vitamin K IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
osteocalcin
Names
bone Gla protein
bone Gla-protein
bone gamma-carboxyglutamate (gla) protein (osteocalcin)
bone gamma-carboxyglutamate protein 2
bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin)
gamma-carboxyglutamic acid-containing protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013414.1NP_038200.1  osteocalcin preproprotein

    See identical proteins and their annotated locations for NP_038200.1

    Status: VALIDATED

    Source sequence(s)
    M25490
    UniProtKB/Swiss-Prot
    P04640
    Related
    ENSRNOP00000026530, OTTRNOP00000001994, ENSRNOT00000026530, OTTRNOT00000003444
    Conserved Domains (1) summary
    smart00069
    Location:3195
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    187741770..187748446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232594.2XP_006232656.1  

    See identical proteins and their annotated locations for XP_006232656.1

    UniProtKB/Swiss-Prot
    P04640
    Conserved Domains (1) summary
    smart00069
    Location:3195
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    167783260..167784237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)