Gdf5 growth differentiation factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gdf5provided by RGD
Official Full Name: growth differentiation factor 5provided by RGD
Primary source: RGD:620102
See related: Ensembl:ENSRNOG00000050123 AllianceGenome:RGD:620102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cdmp1
Summary: Enables signaling receptor binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; ossification involved in bone remodeling; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease and bone disease (multiple). Orthologous to human GDF5 (growth differentiation factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 14.8), Adrenal (RPKM 5.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164914401..164918593, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144454316..144458508, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151482672..151487129, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Title: Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway.
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.
Title: Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.
GDF5 is a potential regulator of nigrostriatal pathway development. GDF5-induced neurite outgrowth from cultured VM DA neurons is dependent on BMP type I receptor activation of the Smad 1/5/8 signalling pathway.
Title: Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons.
GDF5-overexpressing CHO cells secrete Growth Differentiation Factors in vivo after implantation into the adult rat striatum.
Title: Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease.
GDF5 is a potent inducer of chondrogenesis in adipose stem cells
Title: Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells.
Expression of GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14.In the adult rat was found in heart and brain, being expressed in many areas of the brain, including striatum and midbrain.
Title: Expression of growth differentiation factor-5 in the developing and adult rat brain.
Our study showed that GDF-5 promotes the differentiation of rat fat-derived stromal cells into osteogenic lineages in vitro.
Title: Recombinant growth/differentiation factor-5 stimulates osteogenic differentiation of fat-derived stromal cells in vitro.
involved in the formation of periodontal ligament
Title: Gene expression of growth differentiation factors in the developing periodontium of rat molars.

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General gene information

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Markers

UniSTS:496658 (e-PCR)
- UniSTS:496658

Gdf5 (e-PCR), detects polymorphism
- UniSTS:496658

REN57716 (e-PCR)
- UniSTS:382516

REN57733 (e-PCR)
- UniSTS:382533

U08337 (e-PCR)
- UniSTS:159059

UniSTS:143190 (e-PCR)
- UniSTS:143190

Gdf5 (e-PCR), detects polymorphism
- UniSTS:143190

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chondroblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification involved in bone remodeling	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: growth/differentiation factor 5

Names: cartilage-derived morphogenetic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398661.1 → NP_001385590.1 growth/differentiation factor 5 preproprotein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6KI71, M0RAY4

Related

ENSRNOP00000066703.1, ENSRNOT00000073736.4

Conserved Domains (2) summary

cd19399
Location:393 → 495

TGF_beta_GDF5; transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins

cl02928
Location:147 → 338

TGFb_propeptide; TGF-beta propeptide