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    FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) [ Homo sapiens (human) ]

    Gene ID: 2528, updated on 27-Apr-2013
    Official Symbol
    FUT6provided by HGNC
    Official Full Name
    fucosyltransferase 6 (alpha (1,3) fucosyltransferase)provided by HGNC
    Primary source
    HGNC:4017
    See related
    Ensembl:ENSG00000156413; HPRD:00651; MIM:136836; Vega:OTTHUMG00000167335
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FT1A; FCT3A; Fuc-TVI; FucT-VI
    Summary
    The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (5830637..5839742, complement)
    See FUT6 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene dihydrouridine synthase 3-like (S. cerevisiae) Neighboring gene neurturin Neighboring gene fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) Neighboring gene fucosyltransferase 5 (alpha (1,3) fucosyltransferase)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. Lin X, et al. Hum Mol Genet, 2012 Jun 1. PMID 22367966.
    2. Functional analysis of α1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells. Guo Q, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22155250.
    3. Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation. Lauc G, et al. PLoS Genet, 2010 Dec 23. PMID 21203500.
    4. The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach. Trinchera M, et al. Int J Biochem Cell Biol, 2011 Jan. PMID 20965272.
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. these results suggest that FUT6 plays an important role in hepatocellular carcinoma growth by regulating the PI3K/Akt signaling pathway.
      Title: Functional analysis of α1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells.
    2. The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
      Title: The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines
      Title: Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab.
    6. results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT6
      Title: Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.
    7. two defined regions in the 5'-flanking region of the FUT VI transcription start site are critical for FUT VI transcription in HepG2 cells
      Title: Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
    8. endo-beta-galactosidase-sensitive and mAb FH6-reactive carbohydrate chains are generated under the control of expression levels of FUT6 and involved in the adhesion of colon carcinoma cells to liver sections.
      Title: Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion.
    9. 5'UT-exons A or C have higher expression of FUT8 transcripts and higher alpha6-fucosyltransferase activity
      Title: Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.
    10. IL-1 beta-induced sLeX expression on HuH-7 cells was suppressed by transfection of gene-specific small interference RNAs against FUT VI and ST3Gal IV but not against FUT IV and ST3Gal III.
      Title: Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ40754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    alpha-(1->3)-fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    fucosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    L-fucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    fucosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    alpha-(1,3)-fucosyltransferase
    Names
    alpha-(1,3)-fucosyltransferase
    fucosyltransferase VI
    galactoside 3-L-fucosyltransferase
    NP_000141.1
    NP_001035791.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007505.1 RefSeqGene

      Range
      5001..14106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000150.2 → NP_000141.1  alpha-(1,3)-fucosyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC024592, BC061700, DA426469, DA622182, DA628976
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      P51993
      UniProtKB/TrEMBL
      Q6P7E6
      Related
      ENSP00000313398, ENST00000318336
      Conserved Domains (1) summary
      pfam00852
      Location:13 – 358
      Blast Score: 1188
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase)

    2. NM_001040701.1 → NP_001035791.1  alpha-(1,3)-fucosyltransferase

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC024592, BC061700, DA622182, DA628976
      Consensus CDS
      CCDS12152.1
      UniProtKB/Swiss-Prot
      P51993
      UniProtKB/TrEMBL
      Q6P7E6
      Related
      ENSP00000286955, OTTHUMP00000235736, ENST00000286955, OTTHUMT00000394220
      Conserved Domains (1) summary
      pfam00852
      Location:13 – 358
      Blast Score: 1188
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p10 Primary Assembly

      Range
      5830637..5839742, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      5590485..5599559, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018930.1 Alternate CHM1_1.0

      Range
      5755076..5764182, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01055986.1 (29435..38509) None
    genomic AC024592.5 (6014..19305) None
    genomic AMYH01009367.1 (25139..34245) None
    genomic CH471139.2 EAW69136.1
      EAW69137.1
      EAW69138.1
      EAW69139.1
    genomic L01698.1 AAB03078.1
    mRNA AF131211.1 AAD33509.1
    mRNA AK098073.1 None
    mRNA AK225795.1 None
    mRNA AK313130.1 BAG35950.1
    mRNA BC061700.1 AAH61700.1
    mRNA DA426469.1 None
    mRNA DA622182.1 None
    mRNA DA628976.1 None
    mRNA M98825.1 AAA99222.1
    mRNA U27331.1 AAC50190.1
    mRNA U27332.1 AAC50191.1
    mRNA U27333.1 AAC50192.1
    mRNA U27334.1 AAC50193.1
    mRNA U27335.1 AAC50194.1
    mRNA U27336.1 AAC50195.1
    mRNA U27337.1 AAC50196.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51993.1 GenPept UniProtKB/Swiss-Prot:P51993

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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