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FUT4 fucosyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 2526, updated on 26-May-2016
Official Symbol
FUT4provided by HGNC
Official Full Name
fucosyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:4015
See related
Ensembl:ENSG00000196371 HPRD:00083; MIM:104230; Vega:OTTHUMG00000167795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV
Summary
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Orthologs
Location:
11q21
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (94543851..94549898)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94277017..94283064)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRE11 homolog A, double strand break repair nuclease Neighboring gene ankyrin repeat domain 49 Neighboring gene chromosome 11 open reading frame 97 Neighboring gene piwi like RNA-mediated gene silencing 4 Neighboring gene uncharacterized LOC105369436

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-(1->3)-fucosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
fucosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
L-fucose catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
fucosylation IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
alpha-(1,3)-fucosyltransferase 4
Names
ELAM ligand fucosyltransferase
ELAM-1 ligand fucosyltransferase
Lewis X
alpha (1,3) fucosyltransferase, myeloid-specific
fucT-IV
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
fucosyltransferase IV
galactoside 3-L-fucosyltransferase
stage-specific embryonic antigen 1
NP_002024.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002033.3NP_002024.1  alpha-(1,3)-fucosyltransferase 4

    See identical proteins and their annotated locations for NP_002024.1

    Status: REVIEWED

    Source sequence(s)
    AF305083, AP000943, BC136374, BE242611
    Consensus CDS
    CCDS8301.1
    UniProtKB/Swiss-Prot
    P22083
    Related
    ENSP00000351602, OTTHUMP00000236888, ENST00000358752, OTTHUMT00000396327
    Conserved Domains (1) summary
    pfam00852
    Location:154528
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    94543851..94549898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    94160008..94166060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)