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Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 25255, updated on 26-May-2016
Official Symbol
Dyrk1aprovided by RGD
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 1Aprovided by RGD
Primary source
RGD:2528
See related
Ensembl:ENSRNOG00000001662
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Dyrk; PSK47
Summary
catalyzes the phosphorylation of dynamin 1 and regulates dynamin 1 interaction with amphiphysin 1; may regulate assembly of the endocytic apparatus [RGD, Feb 2006]
Orthologs
Location:
11q11
Exon count:
14
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34858340..34958733)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (38453019..38550512)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549457 Neighboring gene 60S ribosomal protein L11-like Neighboring gene DSCR3 arrestin fold containing Neighboring gene uncharacterized LOC103693522 Neighboring gene uncharacterized LOC102550239 Neighboring gene potassium voltage-gated channel subfamily J member 6 Neighboring gene similar to heat shock protein 1, beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
protein self-association ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein deacetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
intracellular ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1A
Names
Dual Specificity Yak1-related kinase
MNBH
RP86
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
protein kinase minibrain homolog
NP_036923.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012791.2NP_036923.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A

    See identical proteins and their annotated locations for NP_036923.1

    Status: PROVISIONAL

    Source sequence(s)
    X79769
    UniProtKB/Swiss-Prot
    Q63470
    Related
    ENSRNOP00000042446, ENSRNOT00000050342
    Conserved Domains (2) summary
    smart00220
    Location:159479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    34858340..34958733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768563.1XP_008766785.1  

    See identical proteins and their annotated locations for XP_008766785.1

    UniProtKB/Swiss-Prot
    Q63470
    Conserved Domains (2) summary
    smart00220
    Location:159479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  2. XM_006248031.2XP_006248093.1  

    See identical proteins and their annotated locations for XP_006248093.1

    UniProtKB/Swiss-Prot
    Q63470
    Conserved Domains (2) summary
    smart00220
    Location:159479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  3. XM_008768564.1XP_008766786.1  

    See identical proteins and their annotated locations for XP_008766786.1

    UniProtKB/Swiss-Prot
    Q63470
    Conserved Domains (2) summary
    smart00220
    Location:159479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  4. XM_008768565.1XP_008766787.1  

    UniProtKB/Swiss-Prot
    Q63470
    Conserved Domains (2) summary
    smart00220
    Location:150470
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:139475
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  5. XM_008768562.1XP_008766784.1  

    See identical proteins and their annotated locations for XP_008766784.1

    UniProtKB/Swiss-Prot
    Q63470
    Conserved Domains (2) summary
    smart00220
    Location:159479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:148484
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    34444072..34535020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)