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Bdkrb2 bradykinin receptor B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25245, updated on 8-May-2016
Official Symbol
Bdkrb2provided by RGD
Official Full Name
bradykinin receptor B2provided by RGD
Primary source
RGD:2201
See related
Ensembl:ENSRNOG00000047300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
B2BKR; B2BRA
Summary
binds bradykinin; mediates bradykinin induced chloride ion flux; plays a role in pain response [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
Location:
6q32
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129399468..129429676)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (138615812..138622272)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100909917 Neighboring gene uncharacterized LOC100909954 Neighboring gene uncharacterized LOC102550757 Neighboring gene uncharacterized LOC103692699 Neighboring gene bradykinin receptor B1 Neighboring gene autophagy related 2B Neighboring gene GSK3B interacting protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
beta-2 adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
bradykinin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
bradykinin receptor activity IEA
Inferred from Electronic Annotation
more info
 
bradykinin receptor activity ISO
Inferred from Sequence Orthology
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
type 1 angiotensin receptor binding IEA
Inferred from Electronic Annotation
more info
 
type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acute inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
maintenance of blood-brain barrier IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt stress IEA
Inferred from Electronic Annotation
more info
 
response to salt stress ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain TAS
Traceable Author Statement
more info
PubMed 
smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
vasodilation IEA
Inferred from Electronic Annotation
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
B2 bradykinin receptor
Names
B2R
BK-2 receptor
bradykinin receptor, beta 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270713.1NP_001257642.1  B2 bradykinin receptor isoform 1

    See identical proteins and their annotated locations for NP_001257642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC125847, M59967
    UniProtKB/TrEMBL
    G3V942
    Related
    ENSRNOP00000064990, ENSRNOT00000074621
    Conserved Domains (1) summary
    pfam00001
    Location:88339
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_173100.2NP_775123.2  B2 bradykinin receptor isoform 2

    See identical proteins and their annotated locations for NP_775123.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125847, M59967, X69681
    UniProtKB/Swiss-Prot
    P25023
    UniProtKB/TrEMBL
    A0A0H2UI29
    Related
    ENSRNOP00000064715, ENSRNOT00000071735
    Conserved Domains (1) summary
    pfam00001
    Location:82333
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    129399468..129429676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    122039524..122069422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)