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FUS FUS RNA binding protein [ Homo sapiens (human) ]

Gene ID: 2521, updated on 26-Oct-2014
Official Symbol
FUSprovided by HGNC
Official Full Name
FUS RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:4010
See related
Ensembl:ENSG00000089280; HPRD:00660; MIM:137070; Vega:OTTHUMG00000132395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2
Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Location:
16p11.2
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (31180110..31194871)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31191431..31206192)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene protease, serine, 8 Neighboring gene protease, serine, 36 Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72, E3 ubiquitin protein ligase Neighboring gene PYD (pyrin domain) containing 1

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, FUS (fused in sarcoma; HNRNPP2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with FUS is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA splicing TAS
Traceable Author Statement
more info
 
cell death IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
RNA-binding protein FUS
Names
RNA-binding protein FUS
oncogene FUS
oncogene TLS
fus-like protein
fused in sarcoma
75 kDa DNA-pairing protein
fusion gene in myxoid liposarcoma
translocated in liposarcoma protein
heterogeneous nuclear ribonucleoprotein P2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012889.2 

    Range
    4979..19740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170634.1NP_001164105.1  RNA-binding protein FUS isoform 2

    See proteins identical to NP_001164105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC009088, AI333366, DC361263
    Consensus CDS
    CCDS58454.1
    UniProtKB/Swiss-Prot
    P35637
    Conserved Domains (3) summary
    COG0724
    Location:263373
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12535
    Location:282367
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:421448
    zf-RanBP; Zn-finger in Ran binding protein and others
  2. NM_001170937.1NP_001164408.1  RNA-binding protein FUS isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC009088, AI333366, DA541747, DC361263, U36561
    UniProtKB/TrEMBL
    Q13344
    Conserved Domains (3) summary
    COG0724
    Location:260370
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12535
    Location:279364
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:418445
    zf-RanBP; Zn-finger in Ran binding protein and others
  3. NM_004960.3NP_004951.1  RNA-binding protein FUS isoform 1

    See proteins identical to NP_004951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009088, AI333366, AW408771, BC002459, DC361263
    Consensus CDS
    CCDS10707.1
    UniProtKB/Swiss-Prot
    P35637
    UniProtKB/TrEMBL
    Q6IBQ5
    Related
    ENSP00000254108, OTTHUMP00000163228, ENST00000254108, OTTHUMT00000255526
    Conserved Domains (3) summary
    COG0724
    Location:264374
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12535
    Location:283368
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:422449
    zf-RanBP; Zn-finger in Ran binding protein and others

RNA

  1. NR_028388.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits an exon in the coding sequence, compared to variant 1, resulting in a frameshift and premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay and thus the truncated protein is not annotated.
    Source sequence(s)
    AC009088, AI333366, AW408771, DC361263

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    31180110..31194871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255233.2XP_005255290.1  

    See proteins identical to XP_005255290.1

    Conserved Domains (3) summary
    COG0724
    Location:63169
    COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
    cd12535
    Location:78163
    RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
    pfam00641
    Location:217244
    zf-RanBP; Zn-finger in Ran binding protein and others

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    28753052..28767812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    32509148..32523909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001010850.1: Suppressed sequence

    Description
    NM_001010850.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.