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Il6st interleukin 6 signal transducer [ Rattus norvegicus (Norway rat) ]

Gene ID: 25205, updated on 26-May-2016
Official Symbol
Il6stprovided by RGD
Official Full Name
interleukin 6 signal transducerprovided by RGD
Primary source
RGD:2903
See related
Ensembl:ENSRNOG00000013963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Gp130; Ac1055; Il-6rb
Summary
IL-6 signal transducing molecule [RGD, Feb 2006]
Orthologs
Location:
2q14-q16
Exon count:
18
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44279206..44319427)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (63320957..63361404)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554784 Neighboring gene uncharacterized LOC103691456 Neighboring gene ankyrin repeat domain 55 Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene interleukin 31 receptor A Neighboring gene DEAD-box helicase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
ciliary neurotrophic factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to growth factor binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-11 binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-11 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-11 receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-11 receptor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-6 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-6 receptor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 receptor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
leukemia inhibitory factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to leukemia inhibitory factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
oncostatin-M receptor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to oncostatin-M receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
ciliary neurotrophic factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ciliary neurotrophic factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-27-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
interleukin-6-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leukemia inhibitory factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
leukemia inhibitory factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
oncostatin-M-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
oncostatin-M-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat1 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat1 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of hormone secretion TAS
Traceable Author Statement
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
ciliary neurotrophic factor receptor complex IEA
Inferred from Electronic Annotation
more info
 
ciliary neurotrophic factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
interleukin-6 receptor complex IEA
Inferred from Electronic Annotation
more info
 
interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
oncostatin-M receptor complex IEA
Inferred from Electronic Annotation
more info
 
oncostatin-M receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-6 receptor subunit beta
Names
IL-6 receptor subunit beta
IL-6R subunit beta
interleukin-6 signal transducer
membrane glycoprotein 130
oncostatin-M receptor subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008725.3NP_001008725.2  interleukin-6 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_001008725.2

    Status: VALIDATED

    Source sequence(s)
    AABR07008118
    UniProtKB/TrEMBL
    H9BFG4
    Related
    ENSRNOP00000018877, ENSRNOT00000018877
    Conserved Domains (3) summary
    cd00063
    Location:221320
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:24114
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:125214
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    44279206..44319427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231928.2XP_006231990.1  

    See identical proteins and their annotated locations for XP_006231990.1

    Conserved Domains (3) summary
    cd00063
    Location:237336
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:40130
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:141230
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_008760736.1XP_008758958.1  

    See identical proteins and their annotated locations for XP_008758958.1

    Conserved Domains (3) summary
    cd00063
    Location:237336
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:40130
    Lep_receptor_Ig; Ig-like C2-type domain
    cl21522
    Location:141230
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_590897.1 RNA Sequence

  2. XR_351404.2 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    39857022..39886283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)