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Esr2 estrogen receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25149, updated on 26-May-2016
Official Symbol
Esr2provided by RGD
Official Full Name
estrogen receptor 2provided by RGD
Primary source
RGD:2582
See related
Ensembl:ENSRNOG00000005343 Vega:OTTRNOG00000001373
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Erb2; ERbeta; ER-beta
Summary
binds estrogen and mediates transcriptional activation [RGD, Feb 2006]
Orthologs
Location:
6q24
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (99164325..99214358, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (108576398..108626196, complement)

Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 1 Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene 60S ribosomal protein L11-like Neighboring gene uncharacterized LOC102555894 Neighboring gene testis expressed 21 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
    Nuclear Receptor transcription pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian ???bottleneck??? genes associated with infertility A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertili...
  • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
    Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
  • Prolactin signaling pathway, conserved biosystem (from KEGG)
    Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
drug binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estradiol binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 
estrogen receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
estrogen response element binding IDA
Inferred from Direct Assay
more info
PubMed 
estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 
estrogen response element binding ISO
Inferred from Sequence Orthology
more info
 
hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
Sertoli cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
amygdala development IEP
Inferred from Expression Pattern
more info
PubMed 
behavioral fear response IDA
Inferred from Direct Assay
more info
PubMed 
brain development ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to magnetism IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
epithelial cell maturation involved in prostate gland development ISO
Inferred from Sequence Orthology
more info
 
estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
female gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
hormone-mediated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular estrogen receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intracellular steroid hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of behavior IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostate gland development IEP
Inferred from Expression Pattern
more info
PubMed 
prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to bisphenol A IEP
Inferred from Expression Pattern
more info
PubMed 
response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to genistein IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to human chorionic gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt IEP
Inferred from Expression Pattern
more info
PubMed 
response to testosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to testosterone IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to water deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterus development ISO
Inferred from Sequence Orthology
more info
 
vagina development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
estrogen receptor beta
Names
estrogen receptor 2 (ER beta)
estrogen receptor 2 beta
nuclear receptor subfamily 3 group A member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012754.1NP_036886.1  estrogen receptor beta

    See identical proteins and their annotated locations for NP_036886.1

    Status: PROVISIONAL

    Source sequence(s)
    U57439
    UniProtKB/Swiss-Prot
    Q62986
    Related
    ENSRNOP00000040505, OTTRNOP00000001230, ENSRNOT00000042682, OTTRNOT00000002117
    Conserved Domains (3) summary
    cd06949
    Location:218453
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:99180
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:179
    ERbeta_N; Estrogen receptor beta

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

    Range
    99164325..99214358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240221.2XP_006240283.1  

    See identical proteins and their annotated locations for XP_006240283.1

    UniProtKB/TrEMBL
    Q59IV8
    Related
    ENSRNOP00000043144, OTTRNOP00000001231, ENSRNOT00000043602, OTTRNOT00000002118
    Conserved Domains (3) summary
    cd06949
    Location:282535
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:163244
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:40143
    ERbeta_N; Estrogen receptor beta

Alternate Rn_Celera

Genomic

  1. AC_000074.1 Alternate Rn_Celera

    Range
    93284596..93334744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)