Aanat aralkylamine N-acetyltransferase [Rattus norvegicus] - Gene

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Summary

Official Symbol: Aanatprovided by RGD
Official Full Name: aralkylamine N-acetyltransferaseprovided by RGD
Primary source: RGD:2006
See related: Ensembl:ENSRNOG00000011182
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Nat4; AA-NAT
Summary: regulates melatonin biosynthesis; may play a role in circadian rhythm and response to photoperiod [RGD, Feb 2006]

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Genomic context

Location :: 10q32.3

Sequence :: Chromosome: 10; NC_005109.2 (106709371..106713683)

See Aanat in MapViewer

Chromosome 10 - NC_005109.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of AANAT in epithelial cells of striated ducts in rat salivary glands.
Title: Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands.
Deletion analysis of N-terminus of AANAT identified the an amino acid leucine (L2) as the key residue that contributes to the proteasomal proteolysis of AANAT protein.
Title: N-terminal residues regulate proteasomal degradation of AANAT.
AANAT mRNA degradation mediated by heterogeneous-muclear ribonucleoproteins hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation.
Title: Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation.
The rapidity of nocturnal AA-NAT induction depends on cAMP inducibility of the gene. Accordingly, cAMP produces a strong AA-NAT response in pineals obtained from rats housed under long photoperiods and a weak AA-NAT response under short photoperiods.
Title: Rat pineal arylalkylamine-N-acetyltransferase: cyclic AMP inducibility of its gene depends on prior entrained photoperiod.
accumulation induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro
Title: Accumulation of rat pineal serotonin N-acetyltransferase mRNA induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro.
aa-nat mRNA increased between 60 and 180 min after the melatonin injection during the light period, while it did not significantly change during the dark period.
Title: Signal transmission from the suprachiasmatic nucleus to the pineal gland via the paraventricular nucleus: analysed from arg-vasopressin peptide, rPer2 mRNA and AVP mRNA changes and pineal AA-NAT mRNA after the melatonin injection during light and dark periods.
the effects of the proteasome inhibitors on NE-stimulated Aanat induction appear to be mediated by accumulation of a protein repressor [review]
Title: Opposite effects of proteasome inhibitors in the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes.
E-box mutations enhanced ectopic expression establishing that the intronic Aanat E-box elements contribute to the gene's pineal specific expression.
Title: Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland.
These findings indicate that the transcriptions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also respond to the ambient light signal in a reduced manner.
Title: Daily oscillation and photoresponses of clock gene, Clock, and clock-associated gene, arylalkylamine N-acetyltransferase gene transcriptions in the rat pineal gland.
serotonin N-acetyltransferase regulation by bradykinin in rat pineal glands is affected by adenylyl cyclase VI
Title: Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands.

Submit: New GeneRIF Correction See all (13)

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Function	Evidence Code	Pubs
aralkylamine N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
aralkylamine N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
aralkylamine N-acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
arylamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
arylamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
entrainment of circadian clock by photoperiod	TAS Traceable Author Statement more info	PubMed
melatonin biosynthetic process	TAS Traceable Author Statement more info	PubMed
metabolic process	ISO Inferred from Sequence Orthology more info
photoperiodism	NAS Non-traceable Author Statement more info	PubMed
response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
response to copper ion	IDA Inferred from Direct Assay more info	PubMed
response to corticosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
response to zinc ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: serotonin N-acetyltransferase

Names: serotonin N-acetyltransferase; serotonin acetylase; Seretonin N-acetyltransferase; arylakylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)

NP_036950.1

EC 2.3.1.87

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012818.2 → NP_036950.1 serotonin N-acetyltransferase

Status: PROVISIONAL

Source sequence(s)

U38306

UniProtKB/Swiss-Prot

Q64666

Related

ENSRNOP00000015221, ENSRNOT00000015221

Conserved Domains (1) summary

cl00357
Location:82 – 172
Blast Score: 127

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005109.2 Reference assembly (based on RGSC_v3.4)

Range

106709371..106713683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000078.1 Alternate assembly (Rn_Celera)

Range

100399613..100403925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473948.1	EDM06682.1
genomic	U77455.2	None	Sprague-Dawley
mRNA	DQ075321.1	AAY86767.1	Sprague-Dawley
mRNA	U29664.1	AAC52330.1	Sprague-Dawley
mRNA	U38306.1	AAB38484.1	Sprague-Dawley
mRNA	U40803.1	AAA92711.1	Sprague-Dawley