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Fgfr4 fibroblast growth factor receptor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25114, updated on 17-May-2016
Official Symbol
Fgfr4provided by RGD
Official Full Name
fibroblast growth factor receptor 4provided by RGD
Primary source
RGD:2612
See related
Ensembl:ENSRNOG00000016763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
fibroblast growth factor receptor subtype expressed in lung and kidney [RGD, Feb 2006]
Orthologs
Location:
17p14
Exon count:
18
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9990072..10004335, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (12099383..12113637, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene hypothetical protein LOC498705 Neighboring gene zinc finger protein 346 Neighboring gene ubiquitin interaction motif containing 1

Homology

Clone Names

  • MGC116290

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
alveolar secondary septum development ISO
Inferred from Sequence Orthology
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast growth factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
organ induction ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
phosphate ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of parathyroid hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of bile acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
regulation of cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phosphorus metabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT response to bile acid ISO
Inferred from Sequence Orthology
more info
 
vacuolar phosphate transport ISO
Inferred from Sequence Orthology
more info
 
vitamin D3 metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 
transport vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibroblast growth factor receptor 4
Names
FGFR-4
NP_001103374.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109904.1NP_001103374.1  fibroblast growth factor receptor 4 precursor

    See identical proteins and their annotated locations for NP_001103374.1

    Status: VALIDATED

    Source sequence(s)
    BC100260, CB743466
    UniProtKB/Swiss-Prot
    Q498D6
    Related
    ENSRNOP00000050988, ENSRNOT00000042394
    Conserved Domains (6) summary
    cd05858
    Location:260347
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:161227
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252346
    IG_like; Immunoglobulin like
    pfam07714
    Location:465741
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:153237
    Ig; Immunoglobulin domain
    cl21453
    Location:452765
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    9990072..10004335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771485.1XP_008769707.1  

    See identical proteins and their annotated locations for XP_008769707.1

    Conserved Domains (6) summary
    cd05858
    Location:260347
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:161227
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252346
    IG_like; Immunoglobulin like
    pfam07714
    Location:464740
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:153237
    Ig; Immunoglobulin domain
    cl21453
    Location:451764
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006253606.2XP_006253668.1  

    Conserved Domains (6) summary
    cd05858
    Location:260347
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00408
    Location:161227
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252346
    IG_like; Immunoglobulin like
    pfam07714
    Location:466742
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:153237
    Ig; Immunoglobulin domain
    cl21453
    Location:453766
    PKc_like; Protein Kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    9540006..9554750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)