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Pc pyruvate carboxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25104, updated on 8-May-2016
Official Symbol
Pcprovided by RGD
Official Full Name
pyruvate carboxylaseprovided by RGD
Primary source
RGD:3262
See related
Ensembl:ENSRNOG00000019372
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcx
Summary
biotin-containing enzyme that catalyses the carboxylation of pyruvate to form oxaloacetate [RGD, Feb 2006]
Orthologs
Location:
1q42
Exon count:
25
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219759167..219859854)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (226626831..226726350)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene synaptotagmin 12 Neighboring gene hypothetical protein LOC689065 Neighboring gene similar to solute carrier family 25, member 5 Neighboring gene similar to hypothetical protein FLJ22531 Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene Ras converting CAAX endopeptidase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
biotin binding IEA
Inferred from Electronic Annotation
more info
 
biotin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
biotin carboxylase activity IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
pyruvate carboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
 
pyruvate carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
oxaloacetate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
positive regulation by host of viral release from host cell IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of viral release from host cell ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
 
viral RNA genome packaging IEA
Inferred from Electronic Annotation
more info
 
viral RNA genome packaging ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
pyruvate carboxylase, mitochondrial
Names
PCB
pyruvic carboxylase
NP_036876.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012744.2NP_036876.2  pyruvate carboxylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_036876.2

    Status: PROVISIONAL

    Source sequence(s)
    U36585
    UniProtKB/Swiss-Prot
    P52873
    Related
    ENSRNOP00000026316, ENSRNOT00000026316
    Conserved Domains (7) summary
    cd06850
    Location:11111177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8611061
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151360
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    219759167..219859854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230691.2XP_006230753.1  

    See identical proteins and their annotated locations for XP_006230753.1

    UniProtKB/Swiss-Prot
    P52873
    Conserved Domains (7) summary
    cd06850
    Location:11121178
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:566849
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:376483
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:341179
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:38146
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8621062
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:152361
    ATP-grasp_4; ATP-grasp domain
  2. XM_008760087.1XP_008758309.1  

    See identical proteins and their annotated locations for XP_008758309.1

    UniProtKB/Swiss-Prot
    P52873
    Conserved Domains (7) summary
    cd06850
    Location:11121178
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:566849
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:376483
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:341179
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:38146
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8621062
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:152361
    ATP-grasp_4; ATP-grasp domain
  3. XM_006230690.2XP_006230752.1  

    Conserved Domains (7) summary
    cd06850
    Location:11131179
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:567850
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:351180
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:39147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8631063
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153362
    ATP-grasp_4; ATP-grasp domain
  4. XM_006230689.2XP_006230751.1  

    UniProtKB/TrEMBL
    A0A0G2JTL5
    Related
    ENSRNOP00000068757, ENSRNOT00000087432
    Conserved Domains (7) summary
    cd06850
    Location:12101276
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:664947
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:474581
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:1321277
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:136244
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:9601160
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:250459
    ATP-grasp_4; ATP-grasp domain
  5. XM_006230693.2XP_006230755.1  

    See identical proteins and their annotated locations for XP_006230755.1

    UniProtKB/Swiss-Prot
    P52873
    Conserved Domains (7) summary
    cd06850
    Location:11111177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8611061
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151360
    ATP-grasp_4; ATP-grasp domain
  6. XM_006230692.2XP_006230754.1  

    See identical proteins and their annotated locations for XP_006230754.1

    UniProtKB/Swiss-Prot
    P52873
    Conserved Domains (7) summary
    cd06850
    Location:11111177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8611061
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151360
    ATP-grasp_4; ATP-grasp domain
  7. XM_006230694.2XP_006230756.1  

    See identical proteins and their annotated locations for XP_006230756.1

    UniProtKB/Swiss-Prot
    P52873
    Conserved Domains (7) summary
    cd06850
    Location:11111177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:331178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:8611061
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151360
    ATP-grasp_4; ATP-grasp domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    199343224..199439273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)