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ALPPL2 alkaline phosphatase, placental like 2 [ Homo sapiens (human) ]

Gene ID: 251, updated on 12-May-2016
Official Symbol
ALPPL2provided by HGNC
Official Full Name
alkaline phosphatase, placental like 2provided by HGNC
Primary source
HGNC:HGNC:441
See related
Ensembl:ENSG00000163286 HPRD:01380; MIM:171810; Vega:OTTHUMG00000133257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALPG; GCAP; ALPPL
Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q37
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (232406842..232410714)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233271552..233275424)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, placental Neighboring gene endothelin converting enzyme-like 1, pseudogene 2 Neighboring gene endothelin converting enzyme-like 1, pseudogene 1 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkaline phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alkaline phosphatase, placental-like
Names
ALP-1
Nagao isozyme
alkaline phosphatase Nagao isozyme
alkaline phosphatase, placental-like 2
germ cell alkaline phosphatase
placental-like alkaline phosphatase
testicular and thymus alkaline phosphatase
NP_112603.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031313.2NP_112603.2  alkaline phosphatase, placental-like preproprotein

    See identical proteins and their annotated locations for NP_112603.2

    Status: REVIEWED

    Source sequence(s)
    AI982769, BC014139, DB194270, J04948
    Consensus CDS
    CCDS2491.1
    UniProtKB/Swiss-Prot
    P10696
    Related
    ENSP00000295453, OTTHUMP00000164356, ENST00000295453, OTTHUMT00000257034
    Conserved Domains (1) summary
    cd00016
    Location:47487
    alkPPc; Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    232406842..232410714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    233277726..233281596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)