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Th tyrosine hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25085, updated on 26-May-2016
Official Symbol
Thprovided by RGD
Official Full Name
tyrosine hydroxylaseprovided by RGD
Primary source
RGD:3853
See related
Ensembl:ENSRNOG00000020410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
The
Summary
catalyzes the rate limiting step in catecholamine biosynthesis; may be involved in response to hypoxia [RGD, Feb 2006]
Orthologs
Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216073034..216080287, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (222935462..222942715, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549750 Neighboring gene uncharacterized LOC102549619 Neighboring gene uncharacterized LOC102549151 Neighboring gene achaete-scute family bHLH transcription factor 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
amino acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
dopamine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ferric iron binding IDA
Inferred from Direct Assay
more info
PubMed 
ferrous iron binding IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
tetrahydrobiopterin binding IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine 3-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine 3-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aminergic neurotransmitter loading into synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
catecholamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to alkaloid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
cerebral cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
circadian sleep/wake cycle IEP
Inferred from Expression Pattern
more info
PubMed 
cognition IEP
Inferred from Expression Pattern
more info
PubMed 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process from tyrosine IDA
Inferred from Direct Assay
more info
PubMed 
dopamine biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine biosynthetic process from tyrosine ISO
Inferred from Sequence Orthology
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
epinephrine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
epinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
eye photoreceptor cell development IEA
Inferred from Electronic Annotation
more info
 
eye photoreceptor cell development ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
glycoside metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
heart development IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
isoquinoline alkaloid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
learning ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
mating behavior IEA
Inferred from Electronic Annotation
more info
 
mating behavior ISO
Inferred from Sequence Orthology
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
multicellular organism aging IEP
Inferred from Expression Pattern
more info
PubMed 
neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
norepinephrine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phthalate metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
phytoalexin metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
protein homotetramerization TAS
Traceable Author Statement
more info
PubMed 
regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to ether IEP
Inferred from Expression Pattern
more info
PubMed 
response to growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to herbicide IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to insecticide IEP
Inferred from Expression Pattern
more info
PubMed 
response to isolation stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to light stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to pyrethroid IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to water deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of sound IEP
Inferred from Expression Pattern
more info
PubMed 
social behavior IEP
Inferred from Expression Pattern
more info
PubMed 
sphingolipid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
terpene metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
visual perception IEA
Inferred from Electronic Annotation
more info
 
visual perception ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
melanosome membrane IEA
Inferred from Electronic Annotation
more info
 
melanosome membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tyrosine 3-monooxygenase
Names
tyrosine 3-hydroxylase
NP_036872.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012740.3NP_036872.1  tyrosine 3-monooxygenase

    See identical proteins and their annotated locations for NP_036872.1

    Status: PROVISIONAL

    Source sequence(s)
    M10244
    UniProtKB/Swiss-Prot
    P04177
    Related
    ENSRNOP00000027682, ENSRNOT00000027682
    Conserved Domains (4) summary
    TIGR01269
    Location:38495
    Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
    pfam12549
    Location:226
    TOH_N; Tyrosine hydroxylase N terminal
    cd04930
    Location:38158
    ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)
    cd03345
    Location:166463
    eu_TyrOH; Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    216073034..216080287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    195642057..195649203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)