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Lipa lipase A, lysosomal acid, cholesterol esterase [ Rattus norvegicus (Norway rat) ]

Gene ID: 25055, updated on 21-Oct-2014
Official Symbol
Lipaprovided by RGD
Official Full Name
lipase A, lysosomal acid, cholesterol esteraseprovided by RGD
Primary source
RGD:3008
See related
Ensembl:ENSRNOG00000019077
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
LAL; Lip1; Chole; Chole2
Summary
hydrolase that is involved in intracellular degradation of cholesteryl esters and triglycerides; mutation in gene causes Wolman's disease [RGD, Feb 2006]
See Lipa in MapViewer
Location:
1q52
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (252816536..252870302, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (260038180..260091819, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene Fas cell surface death receptor Neighboring gene cholesterol 25-hydroxylase Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3

  • Lysosome, organism-specific biosystem (from KEGG)
    Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Lysosome, conserved biosystem (from KEGG)
    Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
  • Phase I, non P450, organism-specific biosystem (from WikiPathways)
    Phase I, non P450, organism-specific biosystemThis pathway lists several phase 1 biotransformations and their related enzymes. '''NOTE:''' This pathway is incomplete, reduction and oxidation enzymes are missing
  • Steroid biosynthesis, organism-specific biosystem (from KEGG)
    Steroid biosynthesis, organism-specific biosystem
    Steroid biosynthesis
  • Steroid biosynthesis, conserved biosystem (from KEGG)
    Steroid biosynthesis, conserved biosystem
    Steroid biosynthesis

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipase activity IEA
Inferred from Electronic Annotation
more info
 
lipase activity ISO
Inferred from Sequence Orthology
more info
 
sterol esterase activity IDA
Inferred from Direct Assay
more info
PubMed 
sterol esterase activity IEA
Inferred from Electronic Annotation
more info
 
sterol esterase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
cytokine production ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
sterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
tissue remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
lysosomal acid lipase/cholesteryl ester hydrolase
Names
lysosomal acid lipase/cholesteryl ester hydrolase
sterol esterase
cholesteryl esterase
lysosomal acid lipase 1
lysosomal acid lipase A
pancreatic cholesterol esterase
acid cholesteryl ester hydrolase
Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25
NP_036864.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012732.3NP_036864.3  lysosomal acid lipase/cholesteryl ester hydrolase precursor

    See proteins identical to NP_036864.3

    Status: PROVISIONAL

    Source sequence(s)
    BC072532
    UniProtKB/TrEMBL
    Q6IMY6
    Related
    ENSRNOP00000025845, ENSRNOT00000025845
    Conserved Domains (2) summary
    PLN02872
    Location:7394
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3596
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 

    Range
    252816536..252870302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760321.1XP_008758543.1  

    See proteins identical to XP_008758543.1

    Conserved Domains (2) summary
    PLN02872
    Location:7394
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3596
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
  2. XM_006231275.2XP_006231337.1  

    See proteins identical to XP_006231337.1

    UniProtKB/TrEMBL
    Q6IMY6
    Conserved Domains (2) summary
    PLN02872
    Location:7394
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3596
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    229136934..229170119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)