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P2rx6 purinergic receptor P2X 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25041, updated on 11-Apr-2024

Summary

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Official Symbol
P2rx6provided by RGD
Official Full Name
purinergic receptor P2X 6provided by RGD
Primary source
RGD:3243
See related
Ensembl:ENSRNOG00000001873 AllianceGenome:RGD:3243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P2x6; P2rxl1; Rnap2x6
Summary
Enables extracellularly ATP-gated cation channel activity. Predicted to be involved in cation transmembrane transport; cell surface receptor signaling pathway; and response to ATP. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is active in glutamatergic synapse and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic specialization membrane. Orthologous to human P2RX6 (purinergic receptor P2X 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 54.0), Lung (RPKM 24.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See P2rx6 in Genome Data Viewer
Location:
11q23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96944167..96956424, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83439922..83450449, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87434929..87445221)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2, pseudogene 2 Neighboring gene uncharacterized LOC108352364 Neighboring gene solute carrier family 7, member 4 Neighboring gene leucine rich repeat containing 74B Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene THAP domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract. Yu Q, et al. Histochem Cell Biol, 2010 Feb. PMID 19946698
  2. Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny. Padilla K, et al. Gene Expr Patterns, 2016 Jul. PMID 27545450
  3. Distribution of the purinegic receptors P2X(4) and P2X(6) during rat gut development. García-Alcocer G, et al. Neurosci Lett, 2012 Feb 16. PMID 22230887
  4. Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors. Schwindt TT, et al. J Mol Neurosci, 2011 Jul. PMID 20617399
  5. The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels. Barrera NP, et al. Biophys J, 2007 Jul 15. PMID 17449665, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2X4 and P2X6 proteins were expressed in a different way during rat small intestine development, showing a higher colocalization coefficient at age P30 in both intestine regions. Those results suggest that purinergic receptors may play a role in intestinal maturation, which is associated with age and intestinal region.
    Title: Differential gene expression patterns and colocalization of ATP-gated P2X6/P2X4 ion channels during rat small intestine ontogeny.
  2. The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp.
    Title: Phenotypes of ATP-activated current associated with their genotypes of P2X1-6 subunits in neurons innervating tooth-pulp.
  3. P2X(4) and P2X(6) purinoreceptors are present in the gut from birth and that they are differentially distributed among regions
    Title: Distribution of the purinegic receptors P2X(4) and P2X(6) during rat gut development.
  4. The P2X6 receptor subunit is widely expressed in neuropils in the whole gray matter except for the dorsal superficial layer of the dorsal horn.
    Title: Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.
  5. Results suggest a direct relationship between purinergic P2X2/6 receptor expression and induction of neuronal differentiation in mitogen-free cultured rat neurospheres.
    Title: Directed differentiation of neural progenitors into neurons is accompanied by altered expression of P2X purinergic receptors.
  6. The P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.
    Title: Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
  7. P2X(2) receptors are trimers, whereas the P2X(6) receptor subunits do not form stable oligomers
    Title: Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellularly ATP-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellularly ATP-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables extracellularly ATP-gated monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
P2X purinoceptor 6
Names
ATP receptor
P2X6 receptor
P2XM
purinergic receptor P2X, ligand-gated ion channel, 6
purinergic receptor P2X-like 1 orphan receptor
purinergic receptor P2X6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012721.2 → NP_036853.2  P2X purinoceptor 6

    See identical proteins and their annotated locations for NP_036853.2

    Status: VALIDATED

    Source sequence(s)
    CO554543, X92070, X97376
    UniProtKB/Swiss-Prot
    P51579, R9PXR5
    UniProtKB/TrEMBL
    A0A8I6ADW0
    Related
    ENSRNOP00000002558.5, ENSRNOT00000002558.7
    Conserved Domains (1) summary
    TIGR00863
    Location:22 → 376
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96944167..96956424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270294.1 → XP_063126364.1  P2X purinoceptor 6 isoform X7

  2. XM_063270292.1 → XP_063126362.1  P2X purinoceptor 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ATC1

  3. XM_039087989.2 → XP_038943917.1  P2X purinoceptor 6 isoform X2

    Related
    ENSRNOP00000096439.1
    Conserved Domains (1) summary
    TIGR00863
    Location:46 → 404
    P2X; cation transporter protein

  4. XM_039087988.2 → XP_038943916.1  P2X purinoceptor 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADW0
    Conserved Domains (1) summary
    TIGR00863
    Location:22 → 415
    P2X; cation transporter protein

  5. XM_039087991.2 → XP_038943919.1  P2X purinoceptor 6 isoform X8

    Conserved Domains (1) summary
    cl02993
    Location:1 → 226
    P2X_receptor; ATP P2X receptor

  6. XM_063270291.1 → XP_063126361.1  P2X purinoceptor 6 isoform X4

  7. XM_039087990.2 → XP_038943918.1  P2X purinoceptor 6 isoform X3

    Conserved Domains (1) summary
    cl02993
    Location:22 → 339
    P2X_receptor; ATP P2X receptor

  8. XM_063270293.1 → XP_063126363.1  P2X purinoceptor 6 isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51579.2 GenPept UniProtKB/Swiss-Prot:P51579

Gene LinkOut

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