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Cth cystathionine gamma-lyase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24962, updated on 8-May-2016
Official Symbol
Cthprovided by RGD
Official Full Name
cystathionine gamma-lyaseprovided by RGD
Primary source
RGD:2443
See related
Ensembl:ENSRNOG00000010658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
H
Summary
putative cystathionine gamma-lyase enzyme [RGD, Feb 2006]
Orthologs
Location:
2q45
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (264267029..264293041, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (282366125..282392112)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene similar to SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Liver regeneration-related protein LRRGR00002) Neighboring gene uncharacterized LOC102546670 Neighboring gene similar to voltage-dependent anion channel 1 Neighboring gene similar to Bcl-XL-binding protein v68

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
L-cysteine desulfhydrase activity IEA
Inferred from Electronic Annotation
more info
 
L-cystine L-cysteine-lyase (deaminating) ISO
Inferred from Sequence Orthology
more info
 
L-cystine L-cysteine-lyase (deaminating) ISS
Inferred from Sequence or Structural Similarity
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cystathionine beta-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
cystathionine gamma-lyase activity ISO
Inferred from Sequence Orthology
more info
 
cystathionine gamma-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
methylselenocysteine deselenhydrase activity TAS
Traceable Author Statement
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
pyridoxal phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
pyridoxal phosphate binding TAS
Traceable Author Statement
more info
PubMed 
selenocystathionine gamma-lyase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cysteine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cysteine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cysteine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cysteine biosynthetic process via cystathionine ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
homocysteine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen sulfide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen sulfide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of aortic smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein sulfhydration ISO
Inferred from Sequence Orthology
more info
 
protein sulfhydration ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine ISO
Inferred from Sequence Orthology
more info
 
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine ISS
Inferred from Sequence or Structural Similarity
more info
 
selenium compound metabolic process TAS
Traceable Author Statement
more info
 
transsulfuration ISO
Inferred from Sequence Orthology
more info
 
transsulfuration TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cystathionine gamma-lyase
Names
CTL target antigen
PRB-RA
cystathionase (cystathionine gamma-lyase)
cysteine-protein sulfhydrase
gamma-cystathionase
probasin-related antigen
NP_058770.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017074.1NP_058770.1  cystathionine gamma-lyase

    See identical proteins and their annotated locations for NP_058770.1

    Status: PROVISIONAL

    Source sequence(s)
    D17370
    UniProtKB/Swiss-Prot
    P18757
    Related
    ENSRNOP00000058914, ENSRNOT00000067843
    Conserved Domains (1) summary
    cd00614
    Location:35394
    CGS_like; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    264267029..264293041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233536.2XP_006233598.1  

    Conserved Domains (1) summary
    cd00614
    Location:26337
    CGS_like; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of ...

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    238776532..238802647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)