Cd4 Cd4 molecule [Rattus norvegicus] - Gene

Help top of page

Summary

Official Symbol: Cd4provided by RGD
Official Full Name: Cd4 moleculeprovided by RGD
Primary source: RGD:2306
See related: Ensembl:ENSRNOG00000016294
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: p55; W3/25
Summary: MHC class II binding protein that may be a candidate gene for collagen-induced arthritis; human CD4 is a receptor required for HIV infection [RGD, Feb 2006]

Help top of page

Genomic context

Location :: 4q42

Sequence :: Chromosome: 4; NC_005103.2 (160988512..161014038, complement)

See Cd4 in MapViewer

Chromosome 4 - NC_005103.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28.
Title: Loss of surface antigens is a conserved feature of apoptotic lymphocytes from several mammalian species.
Clear trend toward worse graft survival in patients with focal C4d after kidney transplantaation.
Title: Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival.
Capillary C4d deposition is a marker of antibody-mediated rejection in kidney transplantation and can be detected by various staining methods.
Title: Analysis of different staining techniques for c4d detection in renal allograft biopsies.
In this EAE model, perivascular cells, microglia and macrophages showed different dynamics; microglial cells expressed CD4 during the recovery phase, suggesting microglial CD4 expression in the resolution of the immune response.
Title: CD4 microglial expression correlates with spontaneous clinical improvement in the acute Lewis rat EAE model.
C4d deposition and cellular infiltrates as markers of acute rejection in rat models of orthotopic lung transplantation.
Title: C4d deposition and cellular infiltrates as markers of acute rejection in rat models of orthotopic lung transplantation.
testicular macrophages expressed the markers CD45 and MAC387 and most also expressed CD4.
Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.

Submit: New GeneRIF Correction

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:247037	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
enzyme binding	IEA Inferred from Electronic Annotation more info
enzyme binding	ISO Inferred from Sequence Orthology more info
glycoprotein binding	IEA Inferred from Electronic Annotation more info
glycoprotein binding	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	ISO Inferred from Sequence Orthology more info
zinc ion binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
T cell differentiation	ISO Inferred from Sequence Orthology more info
T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
T cell selection	ISO Inferred from Sequence Orthology more info
T cell selection	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cell adhesion	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cytokine production	IEA Inferred from Electronic Annotation more info
cytokine production	ISO Inferred from Sequence Orthology more info
defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
immune response	IEA Inferred from Electronic Annotation more info
induction by virus of host cell-cell fusion	IEA Inferred from Electronic Annotation more info
induction by virus of host cell-cell fusion	ISO Inferred from Sequence Orthology more info
maintenance of protein location in cell	IEA Inferred from Electronic Annotation more info
maintenance of protein location in cell	ISO Inferred from Sequence Orthology more info
positive regulation of T cell activation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell activation	ISO Inferred from Sequence Orthology more info
positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
protein palmitoleylation	IEA Inferred from Electronic Annotation more info
protein palmitoleylation	ISO Inferred from Sequence Orthology more info
regulation of T cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane raft	IEA Inferred from Electronic Annotation more info
membrane raft	ISO Inferred from Sequence Orthology more info
plasma membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: T-cell surface glycoprotein CD4

Names: T-cell surface glycoprotein CD4; CD4 antigen; W3/25 antigen; T-cell surface antigen T4/Leu-3

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012705.1 → NP_036837.1 T-cell surface glycoprotein CD4 precursor

Status: PROVISIONAL

Source sequence(s)

M15768

UniProtKB/Swiss-Prot

P05540

Related

ENSRNOP00000021915, ENSRNOT00000021915

Conserved Domains (4) summary

cd07690
Location:30 – 123
Blast Score: 429

Ig1_CD4; First immunoglobulin (Ig) domain of CD4

pfam12104
Location:425 – 452
Blast Score: 128

Tcell_CD4_Cterm; T cell CD4 receptor C terminal region

pfam07686
Location:23 – 135
Blast Score: 120

V-set; Immunoglobulin V-set domain

cl11960
Location:213 – 313
Blast Score: 205

Ig; Immunoglobulin domain