Cd8a CD8a molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Cd8aprovided by RGD
Official Full Name: CD8a moleculeprovided by RGD
Primary source: RGD:2316
See related: Ensembl:ENSRNOG00000007178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary: increased expression on mast cells is induced by nitric oxide; may play a role in inflammatory response [RGD, Feb 2006]

Genomic context

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Location :: 4q33

Sequence :: Chromosome: 4; NC_005103.3 (164017633..164021870)

See Cd8a in MapViewer

Chromosome 4 - NC_005103.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Recovery from Antiglomerular Basement Membrane Glomerulonephritis Is Associated with Glomeruli-Infiltrating CD8alpha+CD11c+MHC Class II+ Cells
Title: Natural recovery from antiglomerular basement membrane glomerulonephritis is associated with glomeruli-infiltrating CD8α+CD11c+MHC class II+ cells.
Two spondylarthritis phenotypes previously observed in different B27/Hubeta(2)m-transgenic lines also occurred in the respective CD8a(-/-)-transgenic rat lines. There was no difference in disease prevalence between CD8a(-/-) rats and CD8a(+/-) rats.
Title: Spondylarthritis in HLA-B27/human beta2-microglobulin-transgenic rats is not prevented by lack of CD8.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Antigen processing and presentation, organism-specific biosystem (from KEGG)
Antigen processing and presentation, organism-specific biosystem
Antigen processing and presentation
Antigen processing and presentation, conserved biosystem (from KEGG)
Antigen processing and presentation, conserved biosystem
Antigen processing and presentation
Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Primary immunodeficiency, organism-specific biosystem (from KEGG)
Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
Primary immunodeficiency, conserved biosystem (from KEGG)
Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
T Cell Receptor Signaling Pathway, organism-specific biosystem
T Cell Receptor Signaling Pathway
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...

General gene information

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Homology

Homologs of the Cd8a gene: The Cd8a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, and chicken.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
T cell mediated immunity	IEA Inferred from Electronic Annotation more info
T cell mediated immunity	ISO Inferred from Sequence Orthology more info
cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
cytotoxic T cell differentiation	IEA Inferred from Electronic Annotation more info
cytotoxic T cell differentiation	ISO Inferred from Sequence Orthology more info
defense response to virus	IEA Inferred from Electronic Annotation more info
defense response to virus	ISO Inferred from Sequence Orthology more info
inflammatory response	NAS Non-traceable Author Statement more info	PubMed
positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD8 alpha chain

Names: T-cell surface glycoprotein CD8 alpha chain; OX-8 membrane antigen; CD8 antigen alpha-chain; CD8 antigen 32 kDa chain; CD8 antigen, alpha chain; CD8 antigen, alpha-chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031538.2 → NP_113726.1 T-cell surface glycoprotein CD8 alpha chain precursor

Status: PROVISIONAL

Source sequence(s)

BC088126

UniProtKB/Swiss-Prot

P07725

Related

ENSRNOP00000009516, ENSRNOT00000009515

Conserved Domains (2) summary

pfam07686
Location:27 – 129
Blast Score: 105

V-set; Immunoglobulin V-set domain

cl11960
Location:36 – 137
Blast Score: 300

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005103.3 Reference Rnor_5.0 Primary Assembly

Range

164017633..164021870

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000072.1 Alternate Rn_Celera

Range

92538482..92542731

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AABR06031460.1 (39583..43820)	None
genomic	AAHX01030764.1 (39398..43647)	None
genomic	CH473957.1	EDL90991.1
		EDL90992.1
mRNA	BC088126.1	AAH88126.1
mRNA	X03015.1	CAA26798.1