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Esr1 estrogen receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24890, updated on 8-May-2016
Official Symbol
Esr1provided by RGD
Official Full Name
estrogen receptor 1provided by RGD
Primary source
RGD:2581
See related
Ensembl:ENSRNOG00000019358 Vega:OTTRNOG00000001366
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Esr; ER-alpha; RNESTROR
Summary
acts as a transcriptional activator when bound to estrogen; may play a role in myocardial regulation [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
1q12
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41192150..41594799)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (42534049..42935434)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene nesprin-1-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATPase binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 
estrogen receptor activity TAS
Traceable Author Statement
more info
PubMed 
estrogen response element binding IEA
Inferred from Electronic Annotation
more info
 
estrogen response element binding ISO
Inferred from Sequence Orthology
more info
 
hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
type 1 metabotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Sertoli cell development IEP
Inferred from Expression Pattern
more info
PubMed 
Sertoli cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen metabolic process IEA
Inferred from Electronic Annotation
more info
 
androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
antral ovarian follicle growth IEA
Inferred from Electronic Annotation
more info
 
antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
 
baculum development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
 
decidualization IEP
Inferred from Expression Pattern
more info
PubMed 
epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
epithelial cell proliferation involved in mammary gland duct elongation IEA
Inferred from Electronic Annotation
more info
 
epithelial cell proliferation involved in mammary gland duct elongation ISO
Inferred from Sequence Orthology
more info
 
intracellular estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular steroid hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development ISO
Inferred from Sequence Orthology
more info
 
mammary gland branching involved in pregnancy IEA
Inferred from Electronic Annotation
more info
 
mammary gland branching involved in pregnancy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of triglyceride metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
osteoblast development IEP
Inferred from Expression Pattern
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
Inferred from Sequence Orthology
more info
 
prostate epithelial cord elongation IEA
Inferred from Electronic Annotation
more info
 
prostate epithelial cord elongation ISO
Inferred from Sequence Orthology
more info
 
protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of branching involved in prostate gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterus development IEA
Inferred from Electronic Annotation
more info
 
uterus development ISO
Inferred from Sequence Orthology
more info
 
vagina development IEA
Inferred from Electronic Annotation
more info
 
vagina development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 
transcriptionally active chromatin IEA
Inferred from Electronic Annotation
more info
 
transcriptionally active chromatin ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
estrogen receptor
Names
Er alpha
estradiol receptor
estrogen receptor 1 (alpha)
estrogen receptor alpha c-terminus splice variant 1-2
estrogen receptor alpha variant delta 4
estrogen receptor protein
nuclear receptor subfamily 3 group A member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012689.1NP_036821.1  estrogen receptor

    See identical proteins and their annotated locations for NP_036821.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00102
    UniProtKB/Swiss-Prot
    P06211
    Related
    ENSRNOP00000026350, OTTRNOP00000001225, ENSRNOT00000026350, OTTRNOT00000002098
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12743
    Location:557600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    41192150..41594799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758703.1XP_008756925.1  

    Conserved Domains (4) summary
    cd06949
    Location:348585
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:218299
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12743
    Location:590633
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    pfam02159
    Location:75219
    Oest_recep; Oestrogen receptor
  2. XM_006227832.2XP_006227894.1  

    See identical proteins and their annotated locations for XP_006227894.1

    UniProtKB/TrEMBL
    D0FYH4
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12743
    Location:557600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor
  3. XM_008758704.1XP_008756926.1  

    See identical proteins and their annotated locations for XP_008756926.1

    UniProtKB/TrEMBL
    D0FYH4
    Related
    ENSRNOP00000072170, ENSRNOT00000081017
    Conserved Domains (4) summary
    cd06949
    Location:315552
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:185266
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12743
    Location:557600
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    pfam02159
    Location:42186
    Oest_recep; Oestrogen receptor

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    36921417..37175762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)