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    Bcl2l1 Bcl2-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24888, updated on 18-May-2013
    Official Symbol
    Bcl2l1provided by RGD
    Official Full Name
    Bcl2-like 1provided by RGD
    Primary source
    RGD:2200
    See related
    Ensembl:ENSRNOG00000007946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bclx; Bcl2l; bcl-X; Bcl-xl
    Summary
    inhibits neuronal apoptosis; may provide neuroprotection against ischemic brian injury [RGD, Feb 2006]
    Location :
    3q41.2
    Sequence :
    Chromosome: 3; NC_005102.3 (154662586..154716802, complement)
    See Bcl2l1 in MapViewer

    Chromosome 3 - NC_005102.3Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1 Neighboring gene cytochrome c oxidase subunit IV isoform 2 (lung) Neighboring gene ribosomal protein S2-like Neighboring gene TPX2, microtubule-associated, homolog (Xenopus laevis) Neighboring gene myosin light chain kinase 2

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    NP_113723.1 AAC23593.1 Bcl2l11    BIND  PubMed The carboxy-terminal region of Bcl2l11 (BOD-S) interacts with Bcl2l1 (Bcl-xL). This interaction was modelled on a demonstrated interaction between rat BOD-S and Bcl-xL from an unspecified species. 
    NP_113723.1 NP_741985.1 Bcl2l11    BIND  PubMed The carboxy-terminal region of Bcl2l11 (BOD-L) interacts with Bcl2l1 (Bcl-xL). This interaction was modelled on a demonstrated interaction between rat BOD-L and Bcl-xL from an unspecified species. 
    NP_113723.1 NP_741986.1 Bcl2l11    BIND  PubMed The carboxy-terminal region of Bcl2l11 (BOD-M) interacts with Bcl2l1 (Bcl-xL). This interaction was modelled on a demonstrated interaction between rat BOD-M and Bcl-xL from an unspecified species. 
    NP_113723.1 NP_476471.1 Hrk    BIND  PubMed DP5 interacts with Bcl-xl. 
    BioGRID:246998 BioGRID:248912 Hspd1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:246998 BioGRID:260847 Mdm2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:246998 BioGRID:248372 Ubc    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-4 Signaling Pathway, organism-specific biosystem
      IL-4 Signaling Pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K_AKT_NFKB pathway, organism-specific biosystem (from WikiPathways)
      PI3K_AKT_NFKB pathway, organism-specific biosystemNFKB is an important transcription factor induced by multiple cellular mechanisms. This pathway diagram depicts the major activators of the pathway and the downsteam genes regulated by the pathway. A...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP1 inflammasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    BH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    BH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    MDM2/MDM4 family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular process regulating host cell cycle in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    germ cell development ISO
    Inferred from Sequence Orthology
    more info
     
    growth ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    response to cycloheximide ISO
    Inferred from Sequence Orthology
    more info
     
    response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic nitrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial part ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    bcl-2-like protein 1
    Names
    bcl-2-like protein 1
    bcl2-L-1
    B cell lymphoma 2 like
    B cell lymphoma like X
    apoptosis regulator Bcl-X

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033670.1NP_001028842.1  bcl-2-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC094213
      UniProtKB/Swiss-Prot
      P53563
      Related
      ENSRNOP00000010762, ENSRNOT00000010762
      Conserved Domains (3) summary
      cd06845
      Location:81194
      Blast Score: 409
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      pfam02180
      Location:127
      Blast Score: 128
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1233
      Blast Score: 839
      bcl-2; apoptosis regulator
    2. NM_001033671.1NP_001028843.1  bcl-2-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AF279286, BC094213, U72349
      UniProtKB/Swiss-Prot
      P53563
      UniProtKB/TrEMBL
      Q548R7
      Conserved Domains (3) summary
      pfam02180
      Location:127
      Blast Score: 129
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1125
      Blast Score: 367
      bcl-2; apoptosis regulator
      cl02575
      Location:81125
      Blast Score: 132
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    3. NM_001033672.1NP_001028844.1  bcl-2-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AY141038
      UniProtKB/TrEMBL
      Q7TS62
      Conserved Domains (3) summary
      cd06845
      Location:81189
      Blast Score: 404
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      pfam02180
      Location:127
      Blast Score: 132
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1188
      Blast Score: 728
      bcl-2; apoptosis regulator
    4. NM_031535.2NP_113723.2  bcl-2-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AY141038, U72349
      UniProtKB/Swiss-Prot
      P53563
      UniProtKB/TrEMBL
      Q7TS62
      Related
      ENSRNOP00000043542, ENSRNOT00000047416
      Conserved Domains (3) summary
      cd06845
      Location:81189
      Blast Score: 404
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      pfam02180
      Location:127
      Blast Score: 132
      BH4; Bcl-2 homology region 4
      TIGR00865
      Location:1188
      Blast Score: 728
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: Build 5.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_5.0 Primary Assembly

    Genomic

    1. NC_005102.3 Reference Rnor_5.0 Primary Assembly

      Range
      154662586..154716802, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      140002906..140053959, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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