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Tbxas1 thromboxane A synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24886, updated on 26-May-2016
Official Symbol
Tbxas1provided by RGD
Official Full Name
thromboxane A synthase 1provided by RGD
Primary source
RGD:3826
See related
Ensembl:ENSRNOG00000007918
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the conversion of prostaglandin H2 into thromboxane A2; mRNA expression increases in a model of hydronephrotic kidney; may play a role in response to injury [RGD, Feb 2006]
Orthologs
Location:
4q21-q22
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (66624181..66846745)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (66481238..66651613)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member L Neighboring gene homeodomain interacting protein kinase 2 Neighboring gene uncharacterized LOC103692101 Neighboring gene poly (ADP-ribose) polymerase family, member 12 Neighboring gene lysine demethylase 7A Neighboring gene chromatin modifying protein 4B-like 1

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
thromboxane-A synthase activity IEA
Inferred from Electronic Annotation
more info
 
thromboxane-A synthase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
thromboxane-A synthase
Names
TXA synthase
TXS
ThromboxA ane synthase 1
cytochrome P450 5A1
thromboxane A synthase 1, platelet
NP_036819.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012687.1NP_036819.1  thromboxane-A synthase

    See identical proteins and their annotated locations for NP_036819.1

    Status: PROVISIONAL

    Source sequence(s)
    D28773
    UniProtKB/Swiss-Prot
    P49430
    Related
    ENSRNOP00000010796, ENSRNOT00000010796
    Conserved Domains (1) summary
    pfam00067
    Location:47530
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    66624181..66846745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762759.1XP_008760981.1  

    Conserved Domains (1) summary
    pfam00067
    Location:4474
    p450; Cytochrome P450
  2. XM_008762761.1XP_008760983.1  

    Conserved Domains (1) summary
    cl12078
    Location:47372
    p450; Cytochrome P450
  3. XM_008762760.1XP_008760982.1  

    Conserved Domains (1) summary
    pfam00067
    Location:3445
    p450; Cytochrome P450

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    62678426..62850218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)