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Ret ret proto-oncogene [ Rattus norvegicus (Norway rat) ]

Gene ID: 24716, updated on 26-May-2016
Official Symbol
Retprovided by RGD
Official Full Name
ret proto-oncogeneprovided by RGD
Primary source
RGD:3556
See related
Ensembl:ENSRNOG00000014751
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in excretory system and enteric nervous system development; human homolog is associated with Hirschsprung disease and Multiple Endocrine Neoplasia type 2 [RGD, Feb 2006]
Orthologs
Location:
4q42
Exon count:
20
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (150202174..150244380, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (216130142..216177139, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene similar to developmental pluripotency-associated 3 Neighboring gene similar to DNA-directed RNA polymerase II 7.6 kDa polypeptide (RPB10) (RPB7.6) (RPABC5) Neighboring gene uncharacterized LOC103692208 Neighboring gene BMS1 ribosome biogenesis factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
Peyer's patch morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Peyer's patch morphogenesis ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
embryonic epithelial tube formation IEA
Inferred from Electronic Annotation
more info
 
embryonic epithelial tube formation ISO
Inferred from Sequence Orthology
more info
 
enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 
enteric nervous system development ISO
Inferred from Sequence Orthology
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane protein proteolysis IEA
Inferred from Electronic Annotation
more info
 
membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neuron cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron maturation IEA
Inferred from Electronic Annotation
more info
 
neuron maturation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric glomerulus development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of metanephric glomerulus development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of serine phosphorylation of STAT3 protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of serine phosphorylation of STAT3 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of serine phosphorylation of STAT3 protein ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to pain IEA
Inferred from Electronic Annotation
more info
 
response to pain ISO
Inferred from Sequence Orthology
more info
 
retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ureter maturation IEA
Inferred from Electronic Annotation
more info
 
ureter maturation ISO
Inferred from Sequence Orthology
more info
 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
proto-oncogene tyrosine-protein kinase receptor Ret
Names
Ret gene for receptor tyrosin
Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease)
receptor tyrosine kinase
NP_001103569.1
NP_036775.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110099.1NP_001103569.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform b precursor

    See identical proteins and their annotated locations for NP_001103569.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and unique C-terminus compared to isoform a.
    Source sequence(s)
    AABR07061871
    Conserved Domains (3) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    cd11304
    Location:173268
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07714
    Location:7251006
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_012643.2NP_036775.2  proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor

    See identical proteins and their annotated locations for NP_036775.2

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AABR07061871
    UniProtKB/Swiss-Prot
    G3V9H8
    Related
    ENSRNOP00000047793, ENSRNOT00000047685
    Conserved Domains (3) summary
    cd05045
    Location:7241013
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    cd11304
    Location:173268
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam07714
    Location:7251006
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    150202174..150244380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    140198457..140240663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)