Ren renin [Rattus norvegicus] - Gene

Help top of page

Summary

Official Symbol: Renprovided by RGD
Official Full Name: reninprovided by RGD
Primary source: RGD:3554
See related: Ensembl:ENSRNOG00000002937
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Ren1; RENAA; RATRENAA
Summary: catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]

Help top of page

Genomic context

Location :: 13q13

Sequence :: Chromosome: 13; NC_005112.2 (46262936..46275213)

See Ren in MapViewer

Chromosome 13 - NC_005112.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study examined angiogenic function and genomic structure of regions surrounding the renin gene.
Title: Characterization of the genomic structure and function of regions influencing renin and angiogenesis in the SS rat.
Although plasma renin activity was suppressed in the angiotensinogen II-infused rats, renin content in the renal medulla was increased. Renin levels in the urine increased.
Title: Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.
Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia.
Title: Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia.
The transfer of chromosome 13 from BN to SS rats (to produce the SS.13BN strain) has cardiovascular effects.
Title: Pharmacogenomic strain differences in cardiovascular sensitivity to propofol.
Imidazolone deposition and renin production in peritubular capillary endothelial cells may play a role in the development of tubulointerstitial fibrosis in insulin-resistant hypertensive rats.
Title: Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats.
Cu/Zn SOD expression was significantly higher in cerebral arteries from Ren1-Brown Norway congenic rats vs. those from Dahl salt-sensitive rats
Title: Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries.
The development of the first rat knockout in the renin-angiotensin system emphasizes the role of renin in BP regulation and kidney function even in the low-renin SS rat.
Title: Creation and characterization of a renin knockout rat.
Amiloride reduces arterial pressure in cyp1a1ren-2 transgenic rats in association with increased renal sodium excretion without affecting renal vascular function
Title: Amiloride lowers arterial pressure in cyp1a1ren-2 transgenic rats without affecting renal vascular function.
Dahl SS renin allele plays a crucial role in endothelial dysfunction present in the cerebral circulation of the Dahl SS rat, even in the absence of elevated dietary salt intake.
Title: Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene.
The data demonstrate that a cytosolic renin exists in cardiomyocytes, which in contradiction to secretory renin protects from necrosis but increases apoptosis.
Title: Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts.

Submit: New GeneRIF Correction See all (36)

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:246843	BioGRID:248838	Tsc1		BioGRID	PubMed	Co-localization

Function	Evidence Code	Pubs
aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
endopeptidase activity	ISO Inferred from Sequence Orthology more info
insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
peptidase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	ISO Inferred from Sequence Orthology more info
receptor binding	IPI Inferred from Physical Interaction more info
receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
angiotensin maturation	IDA Inferred from Direct Assay more info
angiotensin maturation	ISO Inferred from Sequence Orthology more info
cell maturation	IEA Inferred from Electronic Annotation more info
cell maturation	ISO Inferred from Sequence Orthology more info
drinking behavior	IEA Inferred from Electronic Annotation more info
drinking behavior	ISO Inferred from Sequence Orthology more info
NOT establishment of blood-nerve barrier	ISO Inferred from Sequence Orthology more info
hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
kidney development	ISO Inferred from Sequence Orthology more info
male gonad development	IEA Inferred from Electronic Annotation more info
mesonephros development	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info
proteolysis	ISO Inferred from Sequence Orthology more info
regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
regulation of blood volume by renin-angiotensin	ISO Inferred from Sequence Orthology more info
renin-angiotensin regulation of aldosterone production	IEA Inferred from Electronic Annotation more info
renin-angiotensin regulation of aldosterone production	ISO Inferred from Sequence Orthology more info
response to cAMP	IDA Inferred from Direct Assay more info	PubMed
response to cGMP	IDA Inferred from Direct Assay more info	PubMed
response to drug	IDA Inferred from Direct Assay more info	PubMed
response to organic substance	ISO Inferred from Sequence Orthology more info
response to stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasmic part	IDA Inferred from Direct Assay more info	PubMed
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
intracellular	IEA Inferred from Electronic Annotation more info
intracellular	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
soluble fraction	IDA Inferred from Direct Assay more info

General protein information

Preferred Names: renin

Names: renin; angiotensinogenase; renin 1 structural

NP_036774.4

EC 3.4.23.15

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012642.4 → NP_036774.4 renin precursor

Status: PROVISIONAL

Source sequence(s)

BC078878

UniProtKB/Swiss-Prot

P08424

Related

ENSRNOP00000003951, ENSRNOT00000003951

Conserved Domains (3) summary

pfam07966
Location:31 – 64
Blast Score: 88

A1_Propeptide; A1 Propeptide

pfam00026
Location:83 – 401
Blast Score: 1050

Asp; Eukaryotic aspartyl protease

cl11403
Location:76 – 401
Blast Score: 1512

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases.

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005112.2 Reference assembly (based on RGSC_v3.4)

Range

46262936..46275213

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000081.1 Alternate assembly (Rn_Celera)

Range

45129122..45139889

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473958.2	EDM09771.1
		EDM09772.1
genomic	M22746.1	None	Sprague-Dawley
genomic	M37278.1	AAA42031.1
mRNA	AF117820.1	AAD26252.1	Sprague-Dawley
mRNA	AF233692.1	AAF78581.1	Sprague-Dawley
mRNA	BC078878.1	AAH78878.1
mRNA	J02941.1	AAA42030.1
mRNA	S60054.1	AAP13916.1
mRNA	X07033.1	CAA30082.1	Sprague-Dawley

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P08424.2	GenPept	UniProtKB/Swiss-Prot:P08424
Q9JIE2	GenPept	UniProtKB/TrEMBL:Q9JIE2
Q9R258	GenPept	UniProtKB/TrEMBL:Q9R258