Format

Send to:

Choose Destination

ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens (human) ]

Gene ID: 247, updated on 8-May-2016
Official Symbol
ALOX15Bprovided by HGNC
Official Full Name
arachidonate 15-lipoxygenase, type Bprovided by HGNC
Primary source
HGNC:HGNC:434
See related
Ensembl:ENSG00000179593 HPRD:04739; MIM:603697; Vega:OTTHUMG00000108181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
15-LOX-2
Summary
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs
Location:
17p13.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (8039040..8049134)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7942343..7952452)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371517 Neighboring gene guanylate cyclase 2D, retinal Neighboring gene uncharacterized LOC105371518 Neighboring gene arachidonate lipoxygenase 3 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 15-lipoxygenase activity TAS
Traceable Author Statement
more info
 
arachidonate 8(S)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
linoleate 13S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hepoxilin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of growth IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macrophage derived foam cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
prostate gland development NAS
Non-traceable Author Statement
more info
PubMed 
regulation of epithelial cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
arachidonate 15-lipoxygenase B
Names
15-LOX-B
15S-lipoxygenase
arachidonate 15-lipoxygenase 2
arachidonate 15-lipoxygenase type II
arachidonate 15-lipoxygenase, second type
arachidonate omega(6) lipoxygenase
linoleate 13-lipoxygenase 15-LOb
NP_001034219.1
NP_001034220.1
NP_001132.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029482.1 RefSeqGene

    Range
    5001..15095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039130.1NP_001034219.1  arachidonate 15-lipoxygenase B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant d. The encoded isoform (a) is shorter than isoform d.
    Source sequence(s)
    AF468052, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32558.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000369520, ENST00000380173
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:231638
    Lipoxygenase; Lipoxygenase
  2. NM_001039131.1NP_001034220.1  arachidonate 15-lipoxygenase B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has multiple differences in the coding region but maintains the reading frame, compared to variant d. The encoded isoform (b) is shorter than isoform d.
    Source sequence(s)
    AF468053, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS32559.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000460332, OTTHUMP00000258940, ENST00000573359, OTTHUMT00000441175
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:231593
    Lipoxygenase; Lipoxygenase
  3. NM_001141.2NP_001132.2  arachidonate 15-lipoxygenase B isoform d

    See identical proteins and their annotated locations for NP_001132.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AF468051, BC063647, BP327830, CA307212, CA405703
    Consensus CDS
    CCDS11128.1
    UniProtKB/Swiss-Prot
    O15296
    Related
    ENSP00000369530, OTTHUMP00000135321, ENST00000380183, OTTHUMT00000226985
    Conserved Domains (2) summary
    cd01753
    Location:2121
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:231667
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    8039040..8049134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    7951127..7961240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)