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Ptpn1 protein tyrosine phosphatase, non-receptor type 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24697, updated on 26-May-2016
Official Symbol
Ptpn1provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 1provided by RGD
Primary source
RGD:61965
See related
Ensembl:ENSRNOG00000010574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptp
Summary
protein-tyrosine-phosphatase which has only phosphotyrosine phosphatase activity [RGD, Feb 2006]
Orthologs
Location:
3q42
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (164665462..164714641)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (170816897..170866071)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691971 Neighboring gene uncharacterized LOC103691972 Neighboring gene family with sequence similarity 65, member C Neighboring gene uncharacterized LOC102552887 Neighboring gene par-6 family cell polarity regulator beta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC93562

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
poly(A) RNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton reorganization ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum unfolded protein response ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of PERK-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
anchored component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
early endosome ISO
Inferred from Sequence Orthology
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sorting endosome IEA
Inferred from Electronic Annotation
more info
 
sorting endosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 1
Names
PTP-1B
protein-tyrosine phosphatase 1B
NP_036769.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012637.2NP_036769.1  tyrosine-protein phosphatase non-receptor type 1

    See identical proteins and their annotated locations for NP_036769.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081829
    UniProtKB/Swiss-Prot
    P20417
    Related
    ENSRNOP00000014309, ENSRNOT00000014309
    Conserved Domains (2) summary
    smart00194
    Location:3276
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:43276
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    164665462..164714641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235639.2XP_006235701.1  

    Conserved Domains (2) summary
    smart00194
    Location:3276
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:43276
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_006235638.2XP_006235700.1  

    See identical proteins and their annotated locations for XP_006235700.1

    UniProtKB/Swiss-Prot
    P20417
    Conserved Domains (2) summary
    smart00194
    Location:3276
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:43276
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    155215176..155261496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)