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Ptgs1 prostaglandin-endoperoxide synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24693, updated on 4-Jul-2015
Official Symbol
Ptgs1provided by RGD
Official Full Name
prostaglandin-endoperoxide synthase 1provided by RGD
Primary source
RGD:3439
See related
Ensembl:ENSRNOG00000007415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox1; Cox3; Cox-1; Cox-3; Pghs-1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Orthologs
See Ptgs1 in MapViewer
Location:
3p11
Exon count:
11
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (15560685..15582339)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (20869915..20891512)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 18 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene similar to basic transcription factor 3 Neighboring gene olfactory receptor pseudogene 393

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
prostaglandin-endoperoxide synthase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cyclooxygenase pathway IEA
Inferred from Electronic Annotation
more info
 
cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
prostaglandin biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prostaglandin G/H synthase 1
Names
PGH synthase 1
PHS 1
cyclooxygenase 3
cyclooxygenase-1
prostaglandin G/H synthase and cyclooxygenase
prostaglandin H2 synthase 1
NP_058739.4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017043.4NP_058739.4  prostaglandin G/H synthase 1 precursor

    See identical proteins and their annotated locations for NP_058739.4

    Status: VALIDATED

    Source sequence(s)
    BC081816
    UniProtKB/TrEMBL
    Q66HK3
    Related
    ENSRNOP00000010218, ENSRNOT00000010218
    Conserved Domains (3) summary
    cd09816
    Location:92578
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148584
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    15560685..15582339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234063.2XP_006234125.1  

    Conserved Domains (3) summary
    cd09816
    Location:92565
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3572
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:148571
    An_peroxidase; Animal haem peroxidase

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    14295836..14317392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)