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Prl prolactin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24683, updated on 8-May-2016
Official Symbol
Prlprovided by RGD
Official Full Name
prolactinprovided by RGD
Primary source
RGD:3403
See related
Ensembl:ENSRNOG00000017374
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Gha1; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
Summary
induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]
Location:
17p12
Exon count:
5
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39814236..39824299, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (41720751..41730813, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene prolactin-3D1 Neighboring gene Prolactin family 3, subfamily d, member 1 Neighboring gene 60S ribosomal protein L19-like Neighboring gene similar to thymine DNA glycosylase isoform 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
prolactin receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
STAT protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
lactation TAS
Traceable Author Statement
more info
PubMed 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
maternal behavior ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal response to stress IEP
Inferred from Expression Pattern
more info
PubMed 
ovulation cycle IEP
Inferred from Expression Pattern
more info
PubMed 
parturition IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prolactin
Names
growth hormone a1
prolactin family 1, subfamily a, member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012629.1NP_036761.1  prolactin precursor

    See identical proteins and their annotated locations for NP_036761.1

    Status: PROVISIONAL

    Source sequence(s)
    AF022935
    UniProtKB/Swiss-Prot
    P01237
    UniProtKB/TrEMBL
    B5DEM6
    Related
    ENSRNOP00000023412, ENSRNOT00000023412
    Conserved Domains (1) summary
    cd10288
    Location:30226
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    39814236..39824299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253912.2XP_006253974.1  

    See identical proteins and their annotated locations for XP_006253974.1

    UniProtKB/TrEMBL
    B2RYT1
    Conserved Domains (1) summary
    cd10288
    Location:29225
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    37551071..37561021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)