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Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24640, updated on 26-May-2016
Official Symbol
Pfkfb2provided by RGD
Official Full Name
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by RGD
Primary source
RGD:3309
See related
Ensembl:ENSRNOG00000004162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
RH2K
Summary
catalyzes the synthesis and degradation of fructose 2,6-bisphosphate [RGD, Feb 2006]
Orthologs
Location:
13q24-q25
Exon count:
19
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47413453..47440682, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (52502121..52529346, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene Sm protein F-like Neighboring gene complement component 4 binding protein, beta Neighboring gene YOD1 deubiquitinase Neighboring gene similar to specifically androgen-regulated protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
6-phosphofructo-2-kinase activity IEA
Inferred from Electronic Annotation
more info
 
6-phosphofructo-2-kinase activity ISO
Inferred from Sequence Orthology
more info
 
6-phosphofructo-2-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
6-phosphofructo-2-kinase activity TAS
Traceable Author Statement
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fructose-2,6-bisphosphate 2-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
fructose-2,6-bisphosphate 2-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
fructose-2,6-bisphosphate 2-phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
fructose 2,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
fructose 2,6-bisphosphate metabolic process TAS
Traceable Author Statement
more info
PubMed 
fructose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process ISO
Inferred from Sequence Orthology
more info
 
glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
lactate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Names
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart)
6PF-2-K/Fru-2,6-P2ASE heart-type isozyme
6PF-2-K/Fru-2,6-P2ase 2
PFK-2/FBPase-2
PFK/FBPase 2
fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase
NP_001029136.1
NP_001029137.1
NP_536725.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033964.2NP_001029136.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b

    See identical proteins and their annotated locations for NP_001029136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end of the coding sequence compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AABR07020932
    UniProtKB/Swiss-Prot
    Q9JJH5
    Related
    ENSRNOP00000044506, ENSRNOT00000050354
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  2. NM_001033965.2NP_001029137.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a

    See identical proteins and their annotated locations for NP_001029137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AABR07020932
    UniProtKB/Swiss-Prot
    Q9JJH5
    Related
    ENSRNOP00000005729, ENSRNOT00000005729
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  3. NM_080477.3NP_536725.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

    See identical proteins and their annotated locations for NP_536725.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' end of the coding sequence compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BE113134, DY312091, L27084
    UniProtKB/Swiss-Prot
    Q9JJH5
    Related
    ENSRNOP00000030819, ENSRNOT00000037679
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    47413453..47440682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249711.2XP_006249773.1  

    See identical proteins and their annotated locations for XP_006249773.1

    UniProtKB/Swiss-Prot
    Q9JJH5
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  2. XM_006249709.2XP_006249771.1  

    See identical proteins and their annotated locations for XP_006249771.1

    UniProtKB/Swiss-Prot
    Q9JJH5
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  3. XM_006249708.1XP_006249770.1  

    See identical proteins and their annotated locations for XP_006249770.1

    UniProtKB/Swiss-Prot
    Q9JJH5
    UniProtKB/TrEMBL
    R9PXY6
    Related
    ENSRNOP00000044027, ENSRNOT00000050859
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  4. XM_006249707.2XP_006249769.1  

    See identical proteins and their annotated locations for XP_006249769.1

    UniProtKB/Swiss-Prot
    Q9JJH5
    UniProtKB/TrEMBL
    R9PXY6
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  5. XM_006249706.2XP_006249768.1  

    See identical proteins and their annotated locations for XP_006249768.1

    UniProtKB/Swiss-Prot
    Q9JJH5
    UniProtKB/TrEMBL
    R9PXY6
    Conserved Domains (3) summary
    cd07067
    Location:254440
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:29252
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:43198
    AAA_33; AAA domain
  6. XM_006249710.1XP_006249772.1  

    See identical proteins and their annotated locations for XP_006249772.1

    UniProtKB/TrEMBL
    C9DRP6
    Conserved Domains (2) summary
    cd07067
    Location:153339
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cl21455
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_008769425.1XP_008767647.1  

    Conserved Domains (3) summary
    cd07067
    Location:218404
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    pfam01591
    Location:1216
    6PF2K; 6-phosphofructo-2-kinase
    pfam13671
    Location:7162
    AAA_33; AAA domain

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    42498231..42525453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)