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Pdgfb platelet derived growth factor subunit B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24628, updated on 17-May-2016
Official Symbol
Pdgfbprovided by RGD
Official Full Name
platelet derived growth factor subunit Bprovided by RGD
Primary source
RGD:3283
See related
Ensembl:ENSRNOG00000017197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
SIS; c-sis
Summary
may play a role in carotid artery smooth muscle cell proliferation and neointimal formation in response to balloon catheter injury [RGD, Feb 2006]
Orthologs
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121215458..121233092, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (121205505..121223140, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547383 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3B Neighboring gene chromobox 7 Neighboring gene uncharacterized LOC102547448 Neighboring gene ribosomal protein L3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
collagen binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor binding IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IEA
Inferred from Electronic Annotation
more info
 
superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
 
superoxide-generating NADPH oxidase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA replication IEP
Inferred from Expression Pattern
more info
PubMed 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell growth IEP
Inferred from Expression Pattern
more info
PubMed 
cell projection assembly ISO
Inferred from Sequence Orthology
more info
 
cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mycophenolic acid IDA
Inferred from Direct Assay
more info
PubMed 
embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell proliferation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
eye photoreceptor cell development ISO
Inferred from Sequence Orthology
more info
 
glial cell development ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
NOT hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
 
metanephric glomerular mesangial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric glomerular mesangial cell proliferation involved in metanephros development ISO
Inferred from Sequence Orthology
more info
 
monocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphatidylinositol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron remodeling ISO
Inferred from Sequence Orthology
more info
 
paracrine signaling ISO
Inferred from Sequence Orthology
more info
 
paracrine signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion import ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of collagen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glomerular mesangial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular mesangial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hepatic stellate cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hepatic stellate cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hyaluronan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metanephric mesenchymal cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic cell cycle, embryonic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pri-miRNA transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to human chorionic gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retina vasculature development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
substrate-dependent cell migration ISO
Inferred from Sequence Orthology
more info
 
synapse assembly ISO
Inferred from Sequence Orthology
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
platelet-derived growth factor subunit B
Names
PDGF subunit B
PDGF-2
Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis)
pdgf protein
platelet derived growth factor, B polypeptide
platelet-derived growth factor B chain
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031524.1NP_113712.1  platelet-derived growth factor subunit B precursor

    See identical proteins and their annotated locations for NP_113712.1

    Status: VALIDATED

    Source sequence(s)
    BQ782530, CB580369, CB783426, Z14117
    UniProtKB/Swiss-Prot
    Q05028
    UniProtKB/TrEMBL
    G3V882
    Related
    ENSRNOP00000023196, ENSRNOT00000023196
    Conserved Domains (2) summary
    cd00135
    Location:95182
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    pfam04692
    Location:2196
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    121215458..121233092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    107869873..107887412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)