Format

Send to:

Choose Destination

Pah phenylalanine hydroxylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24616, updated on 29-Jul-2016
Official Symbol
Pahprovided by RGD
Official Full Name
phenylalanine hydroxylaseprovided by RGD
Primary source
RGD:3248
See related
Ensembl:ENSRNOG00000004302
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
catalyzes the conversion of phenylalanine to tyrosine; deficiency in humans causes genetic disorder phenylketonuria [RGD, Feb 2006]
Orthologs
Location:
7q13
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28066639..28129772)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (28180707..28245428)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351427 Neighboring gene achaete-scute family bHLH transcription factor 1 Neighboring gene mesoderm posterior 2 homolog Neighboring gene uncharacterized LOC108351428 Neighboring gene uncharacterized LOC103692817

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
amino acid binding IDA
Inferred from Direct Assay
more info
PubMed 
amino acid binding IEA
Inferred from Electronic Annotation
more info
 
cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
phenylalanine 4-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
phenylalanine 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
phenylalanine 4-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-phenylalanine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
aromatic amino acid family metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
pteridine-containing compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tetrahydrobiopterin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
phenylalanine-4-hydroxylase
Names
phe-4-monooxygenase
NP_036751.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012619.2NP_036751.2  phenylalanine-4-hydroxylase

    See identical proteins and their annotated locations for NP_036751.2

    Status: PROVISIONAL

    Source sequence(s)
    BC078881
    UniProtKB/TrEMBL
    Q6AYW2
    Related
    ENSRNOP00000005844, ENSRNOT00000005844
    Conserved Domains (3) summary
    TIGR01268
    Location:20452
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04931
    Location:21110
    ACT_PAH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, phenylalanine hydroxylases (PAH)
    cd03347
    Location:119424
    eu_PheOH; Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic phenylalanine-4-hydroxylase (pro_PheOH), eukaryotic ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    28066639..28129772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765215.2XP_008763437.1  

    Conserved Domains (1) summary
    cd03347
    Location:32337
    eu_PheOH; Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic phenylalanine-4-hydroxylase (pro_PheOH), eukaryotic ...

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    19108301..19168259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)