ALOX15 arachidonate 15-lipoxygenase [Homo sapiens] - Gene

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Summary

Official Symbol: ALOX15provided by HGNC
Official Full Name: arachidonate 15-lipoxygenaseprovided by HGNC
Primary source: HGNC:433
See related: Ensembl:ENSG00000161905; HPRD:01067; MIM:152392; Vega:OTTHUMG00000090746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 15LOX-1; 15-LOX-1

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Genomic context

Location :: 17p13.3

Sequence :: Chromosome: 17; NC_000017.10 (4534214..4544960, complement)

See ALOX15 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.
Title: Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries.
15-lipoxygenase-1 expression loss is associated with cancer cells to terminal cell differentiation evasion.
Title: Mechanistic contribution of ubiquitous 15-lipoxygenase-1 expression loss in cancer cells to terminal cell differentiation evasion.
15-LOX-1 promotes various anti-tumorigenic events, including cell differentiation and apoptosis, and inhibits chronic inflammation, angiogenesis, and metastasis. [review]
Title: 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
STAT6 activation and chromatin remodeling by DNA demethylation and histone acetylation are crucial for transcriptional activation of 15-LOX-1 in cultured Hodgkin lymphoma cells.
Title: Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.
12/15-lipoxygenase-overexpressing transgenic mice have elevated levels of BACE1, whereas 12/15-LO-deficient mice have reduced levels.
Title: Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.
cPLA(2)alpha gene activation by IL-1beta is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop
Title: cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.
15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma
Title: 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma.
Colocalization of Raf-1 to PEBP1 is low in asthmatic tissue and cells compared with normals, whereas there is striking colocalization of 15LO1 with PEBP1 in asthma.
Title: 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
Title: Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
Genetic absence of this enzyme results in a significant reduction in amyloid-beta (Abeta) production and deposition and an improvement of cognitive deficits.
Title: Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.

Submit: New GeneRIF Correction See all (89)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
arachidonate 12-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
arachidonate 15-lipoxygenase activity	IEA Inferred from Electronic Annotation more info
hepoxilin-epoxide hydrolase activity	IEA Inferred from Electronic Annotation more info
iron ion binding	IEA Inferred from Electronic Annotation more info
lipoxygenase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
bone mineralization	IEA Inferred from Electronic Annotation more info
inflammatory response	TAS Traceable Author Statement more info	PubMed
leukotriene biosynthetic process	IEA Inferred from Electronic Annotation more info
lipid metabolic process	NAS Non-traceable Author Statement more info	PubMed
lipoxygenase pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: arachidonate 15-lipoxygenase

Names: arachidonate 15-lipoxygenase; 15-LOX; 15-lipooxygenase-1; arachidonate omega-6 lipoxygenase

NP_001131.3

EC 1.13.11.33

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001140.3 → NP_001131.3 arachidonate 15-lipoxygenase

Status: VALIDATED

Source sequence(s)

BC029032, M23892

Consensus CDS

CCDS11049.1

UniProtKB/Swiss-Prot

P16050

Related

ENSP00000293761, OTTHUMP00000115936, ENST00000293761, OTTHUMT00000207487

Conserved Domains (2) summary

cd01753
Location:2 – 111
Blast Score: 427

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

pfam00305
Location:137 – 654
Blast Score: 1759

Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

4534214..4544960, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

4423571..4434147, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC118754.6 (19477..30223)	None
genomic	AY505111.1	AAR84235.1
genomic	CH471108.2	EAW90427.1
		EAW90428.1
genomic	U63384.1	AAC52118.1
genomic	U88317.1	AAB49305.1
mRNA	AK290309.1	BAF82998.1
mRNA	AK296792.1	BAH12431.1
mRNA	AK296821.1	BAH12437.1
mRNA	AK296904.1	BAH12452.1
mRNA	AK312557.1	BAG35454.1
mRNA	AK316126.1	BAH14497.1
mRNA	BC029032.1	AAH29032.1
mRNA	M23892.1	AAA36182.1
mRNA	M95923.1	AAA35482.1