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Abcc1 ATP binding cassette subfamily C member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24565, updated on 8-May-2016
Official Symbol
Abcc1provided by RGD
Official Full Name
ATP binding cassette subfamily C member 1provided by RGD
Primary source
RGD:3112
See related
Ensembl:ENSRNOG00000022305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrp; Mrp1; Abcc1a; Avcc1a
Summary
ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD, Feb 2006]
Orthologs
Location:
10q11
Exon count:
31
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (549537..672235, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (11232233..11354931, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene DNA repair endonuclease XPF-like Neighboring gene uncharacterized LOC103693255 Neighboring gene hypothetical LOC497848 Neighboring gene similar to 40S ribosomal protein S3a (V-fos transformation effector protein) Neighboring gene FGFR1OP N-terminal like Neighboring gene myosin, heavy chain 11, smooth muscle

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
drug transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
drug transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione S-conjugate-exporting ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid-transporting ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
sphingolipid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
xenobiotic-transporting ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic-transporting ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
daunorubicin transport IC
Inferred by Curator
more info
PubMed 
daunorubicin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug export IDA
Inferred from Direct Assay
more info
PubMed 
drug export IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
drug transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phospholipid efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
multidrug resistance-associated protein 1
Names
ATP-binding cassette sub-family C ( CFTR/MRP) member 1a
ATP-binding cassette sub-family C member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, subfamily C (CFTR/MRP), member 1
LTC4 transporter
leukotriene C(4) transporter
multidrug resistance protein 1
multiple drug resistance-associated protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022281.2NP_071617.2  multidrug resistance-associated protein 1

    See identical proteins and their annotated locations for NP_071617.2

    Status: PROVISIONAL

    Source sequence(s)
    AF487549
    UniProtKB/Swiss-Prot
    Q8CG09
    Related
    ENSRNOP00000044445, ENSRNOT00000044108
    Conserved Domains (4) summary
    TIGR00957
    Location:71531
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:12921512
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:645846
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:326597
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    549537..672235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    11130945..11246232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)