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Jak2 Janus kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24514, updated on 26-May-2016
Official Symbol
Jak2provided by RGD
Official Full Name
Janus kinase 2provided by RGD
Primary source
RGD:2939
See related
Ensembl:ENSRNOG00000059968
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
associated with receptors for erythropoietin, prolactin, growth hormones and interleukin-3; phosphorylated when activated by cytokines [RGD, Feb 2006]
Orthologs
Location:
1q51-q53
Exon count:
25
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247398667..247457521)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (254646160..254706478)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene dynein light chain 1, cytoplasmic-like Neighboring gene uncharacterized LOC103691330 Neighboring gene prohibitin-like Neighboring gene insulin-like 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone kinase activity (H3-Y41 specific) IBA
Inferred from Biological aspect of Ancestor
more info
 
histone kinase activity (H3-Y41 specific) ISO
Inferred from Sequence Orthology
more info
 
histone kinase activity (H3-Y41 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-12 receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 1 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
STAT protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
activation of JAK2 kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of JAK2 kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
activation of MAPKK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-3 ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme linked receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
histone H3-Y41 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-Y41 phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
host programmed cell death induced by symbiont ISO
Inferred from Sequence Orthology
more info
 
interferon-gamma-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-12-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelium development ISO
Inferred from Sequence Orthology
more info
 
mineralocorticoid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphoprotein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of Stat5 protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
tyrosine phosphorylation of Stat1 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of Stat3 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of Stat5 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
tyrosine-protein kinase JAK2
Names
JAK-2
Janus kinase 2 (a protein tyrosine kinase)
NP_113702.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031514.1NP_113702.1  tyrosine-protein kinase JAK2

    See identical proteins and their annotated locations for NP_113702.1

    Status: PROVISIONAL

    Source sequence(s)
    U13396
    UniProtKB/Swiss-Prot
    Q62689
    Related
    ENSRNOP00000071877, ENSRNOT00000087011
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    247398667..247457521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    224147256..224206104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)