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Disc1 disrupted in schizophrenia 1 [ Mus musculus (house mouse) ]

Gene ID: 244667, updated on 28-May-2016
Official Symbol
Disc1provided by MGI
Official Full Name
disrupted in schizophrenia 1provided by MGI
Primary source
MGI:MGI:2447658
See related
Ensembl:ENSMUSG00000043051 Vega:OTTMUSG00000032471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
8 E2; 8 73.26 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (125050148..125263822)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (127578095..127785051)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39281 Neighboring gene translin-associated factor X Neighboring gene uncharacterized LOC102632636 Neighboring gene predicted gene, 30713 Neighboring gene signal-induced proliferation-associated 1 like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein complex scaffold IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cilium assembly ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
nonmotile primary cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nonmotile primary cilium assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
pyramidal neuron migration ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
ciliary base ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
kinesin complex ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
disrupted in schizophrenia 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174853.2NP_777278.2  disrupted in schizophrenia 1 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AJ506179, AL672234, AL731650, AY177673
    Consensus CDS
    CCDS40517.1
    UniProtKB/Swiss-Prot
    Q811T9
    Related
    ENSMUSP00000075145, ENSMUST00000075730
    Conserved Domains (1) summary
    cd00890
    Location:455560
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_174854.2NP_777279.2  disrupted in schizophrenia 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_777279.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AJ506179, AL672234, AL731650, AY177673
    Consensus CDS
    CCDS52707.1
    UniProtKB/Swiss-Prot
    Q811T9
    Related
    ENSMUSP00000095914, ENSMUST00000098311
    Conserved Domains (1) summary
    pfam01920
    Location:459495
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    125050148..125263822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248388.1XP_011246690.1  

    See identical proteins and their annotated locations for XP_011246690.1

    UniProtKB/Swiss-Prot
    Q811T9
    Related
    ENSMUSP00000112410, OTTMUSP00000043041, ENSMUST00000118942, OTTMUST00000080764
    Conserved Domains (1) summary
    pfam01920
    Location:459495
    Prefoldin_2; Prefoldin subunit
  2. XM_006531021.2XP_006531084.1  

    See identical proteins and their annotated locations for XP_006531084.1

    UniProtKB/Swiss-Prot
    Q811T9
    Conserved Domains (1) summary
    pfam01920
    Location:459495
    Prefoldin_2; Prefoldin subunit
  3. XM_011248387.1XP_011246689.1  

    Conserved Domains (1) summary
    pfam01920
    Location:470506
    Prefoldin_2; Prefoldin subunit

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    129364004..129569546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170596.1: Suppressed sequence

    Description
    NM_170596.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.