Format

Send to:

Choose Destination

Hmox1 heme oxygenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24451, updated on 26-May-2016
Official Symbol
Hmox1provided by RGD
Official Full Name
heme oxygenase 1provided by RGD
Primary source
RGD:2806
See related
Ensembl:ENSRNOG00000014117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
Summary
catalyzes the oxidative cleavage of heme to biliverdin [RGD, Feb 2006]
Orthologs
Location:
19p11
Exon count:
5
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (14508634..14515455)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (25622556..25629377)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene zinc finger protein 82 Neighboring gene zinc finger protein 14-like Neighboring gene minichromosome maintenance complex component 5 Neighboring gene RASD family, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
heme binding ISO
Inferred from Sequence Orthology
more info
 
heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
heme oxygenase (decyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell death IDA
Inferred from Direct Assay
more info
PubMed 
cellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to cisplatin ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
heme catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heme catabolic process ISO
Inferred from Sequence Orthology
more info
 
heme metabolic process ISO
Inferred from Sequence Orthology
more info
 
heme oxidation IEA
Inferred from Electronic Annotation
more info
 
heme oxidation ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
liver regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter in response to iron IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter in response to iron ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
wound healing involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
wound healing involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
heme oxygenase 1
Names
heme oxygenase (decycling) 1
heme oxygenase (decyclizing) 1
NP_036712.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012580.2NP_036712.1  heme oxygenase 1

    See identical proteins and their annotated locations for NP_036712.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091164
    UniProtKB/Swiss-Prot
    P06762
    Related
    ENSRNOP00000019192, ENSRNOT00000019192
    Conserved Domains (1) summary
    cd00232
    Location:12218
    HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    14508634..14515455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    13334259..13341080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)