FRK fyn-related kinase [Homo sapiens] - Gene

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Summary

Official Symbol: FRKprovided by HGNC
Official Full Name: fyn-related kinaseprovided by HGNC
Primary source: HGNC:3955
See related: Ensembl:ENSG00000111816; HPRD:05954; MIM:606573; Vega:OTTHUMG00000015424
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GTK; RAK; PTK5
Summary: The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6q21-q22.3

Sequence :: Chromosome: 6; NC_000006.11 (116262693..116381921, complement)

See FRK in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genetic variation near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Title: Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Study searched for mutations in the FRK gene, a recently identified tumor suppressor gene, for the first time in NSCLC. Somatic FRK mutations were found at a very low frequency in NSCLCs.
Title: Mutation analysis of the FRK gene in non-small cell lung cancers.
Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms.
Title: Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Observational study of gene-disease association. (HuGE Navigator)
Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Three common Japanese polymorphisms of the Fyn kinase gene studied in 127 healthy controls and 182 sporadic Alzheimer's disease failed to demonstrate any significant difference.
Title: No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase
Title: Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.
The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002022.1	NP_000312.1	RB1	BIND	PubMed	pRB interacts with Rak.
P42685	P06400	RB1	HPRD	PubMed
BioGRID:108726	BioGRID:111700	PTEN	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:108726	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	TAS Traceable Author Statement more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tyrosine-protein kinase FRK

Names: tyrosine-protein kinase FRK; protein-tyrosine kinase 5; PTK5 protein tyrosine kinase 5; nuclear tyrosine protein kinase RAK

NP_002022.1

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002031.2 → NP_002022.1 tyrosine-protein kinase FRK

Status: REVIEWED

Source sequence(s)

U00803

Consensus CDS

CCDS5103.1

UniProtKB/Swiss-Prot

P42685

Related

ENSP00000357615, OTTHUMP00000017048, ENST00000368626, OTTHUMT00000041924

Conserved Domains (4) summary

cd00174
Location:46 – 107
Blast Score: 168

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

cd05068
Location:227 – 490
Blast Score: 1431

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

cd10369
Location:112 – 207
Blast Score: 503

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

pfam07714
Location:234 – 487
Blast Score: 1043

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

116262693..116381921, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

113842168..113962110, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL121963.10	CAB87592.2
genomic	AL357141.8	CAI16469.1
genomic	CH471051.2	EAW48241.1
mRNA	AK302264.1	BAG63611.1
mRNA	AK313314.1	BAG36119.1
mRNA	BC012916.1	AAH12916.1
mRNA	U00803.1	AAA18284.1
mRNA	U22322.1	AAC50116.1
other-genetic	DQ894643.2	ABM85569.1