Grm5 glutamate receptor, metabotropic 5 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Grm5provided by RGD
Official Full Name: glutamate receptor, metabotropic 5provided by RGD
Primary source: RGD:2746
See related: Ensembl:ENSRNOG00000016429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: mGluR5; mGlur5
Summary: may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor [RGD, Feb 2006]

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Genomic context

Location :: 1q32

Sequence :: Chromosome: 1; NC_005100.2 (143857225..144477419)

See Grm5 in MapViewer

Chromosome 1 - NC_005100.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A model of successful cognitive aging with a critical role for mGluR5, Homer 1 proteins and downstream signalling pathways is proposed here.
Title: Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways.
Taken together with our previous results, it is suggested that mGluR1 be involved in tonic inhibition of EC-HIP synaptic enhancement, while mGluR5 be involved in maintenance of persistent inflammatory pain-associated EC-HIP synaptic enhancement.
Title: Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways.
the importance of intracellular mGluR5 in the cascade of events associated with sustained synaptic transmission
Title: Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.
Exogenous activation of mGluR1/5 produces GABAergic inhibition under normal conditions.
Title: Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
Selective inhibition of conventional PKC isoenzymes or preventing changes in [Ca(2)](i) concentration by BAPTA-AM loading was without effect on mGlu receptor-stimulated [(3)H]IP(x) accumulation.
Title: Defining protein kinase/phosphatase isoenzymic regulation of mGlu₅ receptor-stimulated phospholipase C and Ca²⁺ responses in astrocytes.
Three types of glutamate receptors (mGluR5, AMPA and NMDA) cooperate in the modulation of the grade and duration of activation of the nitric oxide-cyclic GMP pathway in cerebellum in vivo.
Title: Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors.
mGluR5 regulates plasticity phenomena in the visual cortex by means of distinct mGluR-dependent processes.
Title: Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor, mGluR5.
Type-5 metabotropic glutamate receptor (mGluR5)-positive allosteric modulators affect the extinction of cocaine-seeking behavior in rats with a history of intravenous cocaine self-administration.
Title: mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.
Positive allosteric modulation of mGluR5 reverses memory deficits induced by methamphetamine self-administration.
Title: Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5.
Shank3 protein has a role in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
Title: Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

Submit: New GeneRIF Correction See all (108)

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_058708.1	NP_620249.1	Grasp	BIND	PubMed	The amino-terminal PDZ domain of Tamalin interacts with the carboxy-terminal PDZ binding domain of mGluR5.
NP_058708.1	AAC53113.1	Homer1	BIND	PubMed	Homer interacts with mGluR5.
NP_058708.1	CAB77249.1	Homer1	BIND	PubMed	Homer 1a interacts with Grm5 (mGluR5). This interaction was modeled on a demonstrated interaction between rat Homer 1a and Grm5 from an unspecified species.
NP_058708.1	NP_113895.1	Homer1	BIND	PubMed	Homer 1c interacts with Grm5 (mGluR5). This interaction was modeled on a demonstrated interaction between rat Homer 1c and Grm5 from an unspecified species.
NP_058708.1	NP_071943.1	Ppp1cc	BIND	PubMed	The amino terminus and core of PP1-gamma-1 interacts with the carboxy-terminal KSVTW motif of mGluR5a.
P31424	NP_071943.1	Ppp1cc	BIND	PubMed	The amino terminus and core of PP1-gamma-1 interacts with the carboxy-terminal KSVTW motif of mGluR5b.
BioGRID:246583	BioGRID:158525	FLNA	BioGRID	PubMed	Two-hybrid
BioGRID:246583	BioGRID:121384	GOPC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:246583	BioGRID:259492	Gopc	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:246583	BioGRID:248756	Shank3	BioGRID	PubMed	Reconstituted Complex
BioGRID:246583	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
A2A adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
PDZ domain binding	TAS Traceable Author Statement more info	PubMed
PLC activating G-protein coupled glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
calmodulin binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
activation of MAPKKK activity	IDA Inferred from Direct Assay more info	PubMed
activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	TAS Traceable Author Statement more info	PubMed
desensitization of G-protein coupled receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger	TAS Traceable Author Statement more info	PubMed
learning	IEA Inferred from Electronic Annotation more info
learning	ISO Inferred from Sequence Orthology more info
locomotory behavior	IEA Inferred from Electronic Annotation more info
locomotory behavior	ISO Inferred from Sequence Orthology more info
negative regulation of locomotion	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
positive regulation of long-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasm	ISO Inferred from Sequence Orthology more info
dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
dendritic spine	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info
postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
postsynaptic membrane	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: metabotropic glutamate receptor 5

Names: metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor (mGluR5)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017012.1 → NP_058708.1 metabotropic glutamate receptor 5 precursor

Status: PROVISIONAL

Source sequence(s)

D10891

UniProtKB/Swiss-Prot

P31424

Related

ENSRNOP00000040016, ENSRNOT00000050639

Conserved Domains (5) summary

cd06374
Location:26 – 496
Blast Score: 2292

PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor

pfam10606
Location:1121 – 1171
Blast Score: 228

GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

pfam07562
Location:507 – 557
Blast Score: 211

NCD3G; Nine Cysteines Domain of family 3 GPCR

pfam00003
Location:588 – 824
Blast Score: 738

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:67 – 471
Blast Score: 672

ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005100.2 Reference assembly (based on RGSC_v3.4)

Range

143857225..144477419

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000069.1 Alternate assembly (Rn_Celera)

Range

139643467..140193665

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AF035009.1	None	W
genomic	CH473956.2	EDM18590.1
		EDM18591.1
mRNA	D10891.1	BAA01711.1	Sprague-Dawley
mRNA	EU559292.1	ACB45671.1	W