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Nr3c1 nuclear receptor subfamily 3, group C, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24413, updated on 22-May-2016
Official Symbol
Nr3c1provided by RGD
Official Full Name
nuclear receptor subfamily 3, group C, member 1provided by RGD
Primary source
RGD:2741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
GR; Gcr; Grl
Summary
glucocorticoid receptor that binds and activates hormone-dependent transcriptional enhancers [RGD, Feb 2006]
Orthologs
Location:
18p12
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31728373..32673988, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (32347227..32348480, complement) , (31408742..31442725, complement)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694197 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene Nedd4 family interacting protein 1 Neighboring gene uncharacterized LOC102547564 Neighboring gene uncharacterized LOC100911367 Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC103694198 Neighboring gene uncharacterized LOC102556326 Neighboring gene uncharacterized LOC102555677 Neighboring gene fibroblast growth factor 1 Neighboring gene uncharacterized LOC102547511 Neighboring gene sprouty RTK signaling antagonist 4 Neighboring gene poly(A) binding protein, cytoplasmic 2 Neighboring gene Yip1 domain family, member 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
    Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
Hsp70 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor activity ISO
Inferred from Sequence Orthology
more info
 
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein dimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid binding IPI
Inferred from Physical Interaction
more info
PubMed 
steroid binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone binding IEA
Inferred from Electronic Annotation
more info
 
steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
steroid hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor activity, sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
Inferred from Electronic Annotation
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adrenal gland development ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
androgen metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to dexamethasone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to steroid hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin-mediated maintenance of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucocorticoid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lung development IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
maternal behavior ISO
Inferred from Sequence Orthology
more info
 
muscle atrophy IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of glucocorticoid mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of vascular permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glucocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to inactivity IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012576.2NP_036708.2  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_036708.2

    Status: VALIDATED

    Source sequence(s)
    AABR03110958, CB699574, Y00489, Y12264
    UniProtKB/Swiss-Prot
    P06536
    Conserved Domains (3) summary
    cd07076
    Location:548794
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:435512
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27420
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    31728373..32673988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772066.1XP_008770288.1  

    See identical proteins and their annotated locations for XP_008770288.1

    Conserved Domains (3) summary
    cd07076
    Location:548794
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:435512
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27420
    GCR; Glucocorticoid receptor
  2. XM_008772065.1XP_008770287.1  

    See identical proteins and their annotated locations for XP_008770287.1

    Conserved Domains (3) summary
    cd07076
    Location:548794
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:435512
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27420
    GCR; Glucocorticoid receptor

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    30905394..30993522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)