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Gck glucokinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24385, updated on 8-May-2016
Official Symbol
Gckprovided by RGD
Official Full Name
glucokinaseprovided by RGD
Primary source
RGD:2670
See related
Ensembl:ENSRNOG00000061527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
GLUKA; RNGK2
Summary
catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; may mediate glucosensing in glucose-inhibited and glucose-excited neurons [RGD, Feb 2006]
Orthologs
Location:
14q21
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86149146..86191576, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (86832735..86875295, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene polymerase (DNA) delta 2, accessory subunit Neighboring gene myosin light chain 7 Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene calcium/calmodulin-dependent protein kinase II beta Neighboring gene segmentation polarity homeobox protein engrailed-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucokinase activity IEA
Inferred from Electronic Annotation
more info
 
glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose binding IDA
Inferred from Direct Assay
more info
PubMed 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
glucose binding IPI
Inferred from Physical Interaction
more info
PubMed 
glucose binding ISO
Inferred from Sequence Orthology
more info
 
glucose binding ISS
Inferred from Sequence or Structural Similarity
more info
 
hexokinase activity ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NADP metabolic process IEA
Inferred from Electronic Annotation
more info
 
NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
calcium ion import IEA
Inferred from Electronic Annotation
more info
 
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to leptin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
detection of glucose IDA
Inferred from Direct Assay
more info
PubMed 
detection of glucose IEA
Inferred from Electronic Annotation
more info
 
detection of glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of glucose ISO
Inferred from Sequence Orthology
more info
 
detection of glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of glucose NAS
Non-traceable Author Statement
more info
PubMed 
fructose 2,6-bisphosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
response to glucose IEP
Inferred from Expression Pattern
more info
PubMed 
second-messenger-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glucokinase
Names
HK IV
HK4
glucokinase variant 3
hexokinase type IV
hexokinase-4
hexokinase-D
NP_001257778.1
NP_001257779.1
NP_036697.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270849.1NP_001257778.1  glucokinase isoform 1

    See identical proteins and their annotated locations for NP_001257778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    X53589
    UniProtKB/TrEMBL
    Q64596
    Related
    ENSRNOP00000068656, ENSRNOT00000080147
    Conserved Domains (2) summary
    cd00012
    Location:108291
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    pfam03727
    Location:252489
    Hexokinase_2; Hexokinase
  2. NM_001270850.1NP_001257779.1  glucokinase isoform 3

    See identical proteins and their annotated locations for NP_001257779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region and uses two alternate splice junctions compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and contains two alternate internal segments compared to isoform 1.
    Source sequence(s)
    AC110110, X53588
    UniProtKB/Swiss-Prot
    P17712
    Related
    ENSRNOP00000069954, ENSRNOT00000086474
    Conserved Domains (3) summary
    cd00012
    Location:75241
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    COG5026
    Location:8441
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam03727
    Location:202439
    Hexokinase_2; Hexokinase
  3. NM_012565.2NP_036697.1  glucokinase isoform 2

    See identical proteins and their annotated locations for NP_036697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon and uses an alternate splice junction at the 3' end of another coding exon compared to variant 1. The resulting isoform (2) has the same N-and C-termini but differs in an internal segment compared to isoform 1.
    Source sequence(s)
    X53588, X53589
    UniProtKB/Swiss-Prot
    P17712
    UniProtKB/TrEMBL
    Q64596
    Related
    ENSRNOP00000071435, ENSRNOT00000086343
    Conserved Domains (3) summary
    cd00012
    Location:75258
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    COG5026
    Location:16458
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam03727
    Location:219456
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    86149146..86191576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251179.2XP_006251241.1  

    See identical proteins and their annotated locations for XP_006251241.1

    UniProtKB/Swiss-Prot
    P17712
    UniProtKB/TrEMBL
    X2G6B3
    Conserved Domains (3) summary
    cd00012
    Location:75258
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    COG5026
    Location:8458
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam03727
    Location:219456
    Hexokinase_2; Hexokinase

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    79669432..79710739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)