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G6pd glucose-6-phosphate dehydrogenase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24377, updated on 26-May-2016
Official Symbol
G6pdprovided by RGD
Official Full Name
glucose-6-phosphate dehydrogenaseprovided by RGD
Primary source
RGD:2645
See related
Ensembl:ENSRNOG00000056728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
G6pdx
Summary
catalyzes the first rate-limiting step in the pentose phosphate pathway; may mediate peroxynitrite functions in neuroprotection against nitric oxide-mediated apoptosis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
chromosome: X
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156274800..156293935)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (152015532..152034676)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1768 Neighboring gene uncharacterized LOC103694529 Neighboring gene similar to ESO3 protein Neighboring gene inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma Neighboring gene family with sequence similarity 3, member A Neighboring gene solute carrier family 10, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
NADP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
NADP binding ISO
Inferred from Sequence Orthology
more info
 
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
glucose binding IDA
Inferred from Direct Assay
more info
PubMed 
glucose binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose binding ISO
Inferred from Sequence Orthology
more info
 
glucose-6-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose-6-phosphate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
NADP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NADPH regeneration IEA
Inferred from Electronic Annotation
more info
 
NADPH regeneration ISO
Inferred from Sequence Orthology
more info
 
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cytokine production ISO
Inferred from Sequence Orthology
more info
 
erythrocyte development ISO
Inferred from Sequence Orthology
more info
 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
glucose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein glutathionylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein glutathionylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
pentose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
pentose biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
PubMed 
pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
pentose-phosphate shunt, oxidative branch IMP
Inferred from Mutant Phenotype
more info
PubMed 
pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to food IEP
Inferred from Expression Pattern
more info
PubMed 
response to iron(III) ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
ribose phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ribose phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
substantia nigra development IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development ISO
Inferred from Sequence Orthology
more info
 
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glucose-6-phosphate 1-dehydrogenase
Names
glucose-6-phosphate dehydrogenase X-linked
NP_058702.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017006.2NP_058702.1  glucose-6-phosphate 1-dehydrogenase

    See identical proteins and their annotated locations for NP_058702.1

    Status: VALIDATED

    Source sequence(s)
    BC081820, CB729647
    UniProtKB/Swiss-Prot
    P05370
    Related
    ENSRNOP00000075297, ENSRNOT00000080887
    Conserved Domains (3) summary
    pfam00479
    Location:35210
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:212506
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
    TIGR00871
    Location:30506
    zwf; glucose-6-phosphate 1-dehydrogenase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    156274800..156293935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    135676941..135696556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)