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Fgb fibrinogen beta chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 24366, updated on 8-May-2016
Official Symbol
Fgbprovided by RGD
Official Full Name
fibrinogen beta chainprovided by RGD
Primary source
RGD:2604
See related
Ensembl:ENSRNOG00000007092 Vega:OTTRNOG00000001393
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab1-181; Ab1-216; Ac1-581
Summary
cleaved by thrombin; plays a role in wound healing [RGD, Feb 2006]
Orthologs
Location:
2q31-q34
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182027100..182037123, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (201442664..201449657, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen alpha chain Neighboring gene pleiotropic regulator 1 Neighboring gene dachsous cadherin-related 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding, bridging IEA
Inferred from Electronic Annotation
more info
 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to receptor binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
blood coagulation, fibrin clot formation IEA
Inferred from Electronic Annotation
more info
 
blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to leptin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
induction of bacterial agglutination IEA
Inferred from Electronic Annotation
more info
 
induction of bacterial agglutination ISO
Inferred from Sequence Orthology
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
protein polymerization IEA
Inferred from Electronic Annotation
more info
 
protein polymerization ISO
Inferred from Sequence Orthology
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
fibrinogen complex IEA
Inferred from Electronic Annotation
more info
 
fibrinogen complex ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule IEA
Inferred from Electronic Annotation
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibrinogen beta chain
Names
fibrinogen, B beta polypeptide
fibrinogen, beta polypeptide
liver regeneration-related protein LRRG036/LRRG043/LRRG189

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020071.2NP_064456.2  fibrinogen beta chain precursor

    See identical proteins and their annotated locations for NP_064456.2

    Status: PROVISIONAL

    Source sequence(s)
    BC088102
    UniProtKB/Swiss-Prot
    P14480
    Related
    ENSRNOP00000009813, OTTRNOP00000001246, ENSRNOT00000009813, OTTRNOT00000002146
    Conserved Domains (2) summary
    pfam08702
    Location:78223
    Fib_alpha; Fibrinogen alpha/beta chain family
    cd00087
    Location:226475
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    182027100..182037123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761078.1XP_008759300.1  

    See identical proteins and their annotated locations for XP_008759300.1

    UniProtKB/Swiss-Prot
    P14480
    Related
    ENSRNOP00000050663, OTTRNOP00000001245, ENSRNOT00000040708, OTTRNOT00000002145
    Conserved Domains (2) summary
    pfam08702
    Location:77222
    Fib_alpha; Fibrinogen alpha/beta chain family
    cd00087
    Location:225461
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  2. XM_006232524.2XP_006232586.1  

    Conserved Domains (2) summary
    pfam08702
    Location:77222
    Fib_alpha; Fibrinogen alpha/beta chain family
    cd00087
    Location:225474
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    162422542..162429467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)