Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Ets1provided by RGD
Official Full Name: v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)provided by RGD
Primary source: RGD:2583
See related: Ensembl:ENSRNOG00000008941
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Tpl1; Ets-1; Etsoncb
Summary: activates transcription of cyclin-dependent kinase inhibitor p21WAF1/Cip1; plays a role in inhibition of apoptosis [RGD, Feb 2006]

Genomic context

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Location :: 8q21

Sequence :: Chromosome: 8; NC_005107.3 (33858347..33921593)

See Ets1 in MapViewer

Chromosome 8 - NC_005107.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Decreased expression of Ets-1 and increased expression of TIMP-2 may play an important role in the development of glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy
Title: Renal expression of proto-oncogene Ets-1 on matrix remodeling in experimental diabetic nephropathy.
Ets-1 may participate and play an important role in the regulation of follicular development, corpus luteum formation, maintenance, and regression in estrus and pregnancy in rats.
Title: Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.
Ets transcription factors play important roles for basic properties of rat C6 glioma cells, and targeting of these factors may become a useful tool for therapeutic strategies against malignant gliomas.
Title: Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes.
Ang II-induced osteopontin expression in vascular smooth muscle cells is mediated by signaling cascades involving G(q/11) the Ras-ERK axis, and the Src kinase family, and by the transcription factor, Ets-1.
Title: Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1.
Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells.
Title: Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells.
Ets family members Ets-1 and Elk-1 can positively regulate COX-2 promoter activity.
Title: Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells.
VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy.
Title: Coordinated expression of Ets-1, pERK1/2, and VEGF in retina of streptozotocin-induced diabetic rats.
diabetes may contribute to increased cell proliferation due to N-ras constitutive activation, as well as to enhanced invasion and metastatic potential by increasing ets-1 levels
Title: Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential.
Despite lacking an obvious motif for a canonical D-site sequence, recognized by ERK2 and used to promote catalysis, transcription factor Ets-1 is efficiently phosphorylated by ERK2 and is shown to interact with it.
Title: Expanding the repertoire of an ERK2 recruitment site: cysteine footprinting identifies the D-recruitment site as a mediator of Ets-1 binding.
Ets-1 has a role in regulation of p21WAF1/Cip1
Title: Ets-1 protects vascular smooth muscle cells from undergoing apoptosis by activating p21WAF1/Cip1: ETS-1 regulates basal and and inducible p21WAF1/Cip: ETS-1 regulates basal and inducible p21WAF1/Cip1 transcription via distinct cis-acting elements in the p21WAF/Cip1 promoter.

Submit: New GeneRIF Correction See all (18)

Pathways from BioSystems

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Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
Dorso-ventral axis formation, organism-specific biosystem
Dorso-ventral axis formation
Dorso-ventral axis formation, conserved biosystem (from KEGG)
Dorso-ventral axis formation, conserved biosystem
Dorso-ventral axis formation
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-4 Signaling Pathway, organism-specific biosystem
IL-4 Signaling Pathway
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem
TGF-beta Receptor Signaling Pathway

General gene information

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Markers

D8Wox27 (e-PCR)
- UniSTS:239874

ETS1 (e-PCR), detects polymorphism
- UniSTS:278354

RH94408 (e-PCR)
- UniSTS:119656

RH138700 (e-PCR)
- UniSTS:220787

RH94700 (e-PCR)
- UniSTS:119947

RH94701 (e-PCR)
- UniSTS:119948

WS29 (e-PCR)
- UniSTS:677

RH142868 (e-PCR)
- UniSTS:232115

D8Rat221 (e-PCR), detects polymorphism
- UniSTS:228286

D8Wox17 (e-PCR)
- UniSTS:517855

RH139077 (e-PCR)
- UniSTS:221163

AI196000 (e-PCR)
- UniSTS:165619

Homology

Homologs of the Ets1 gene: The Ets1 gene is conserved in human, Rhesus monkey, dog, cow, mouse, and chicken.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
DNA binding	ISO Inferred from Sequence Orthology more info
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
PML body organization	IEA Inferred from Electronic Annotation more info
PML body organization	ISO Inferred from Sequence Orthology more info
angiogenesis involved in wound healing	IEP Inferred from Expression Pattern more info	PubMed
cell motility	IEA Inferred from Electronic Annotation more info
cell motility	ISO Inferred from Sequence Orthology more info
cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
estrous cycle phase	IEP Inferred from Expression Pattern more info	PubMed
female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
induction of apoptosis	IEA Inferred from Electronic Annotation more info
induction of apoptosis	ISO Inferred from Sequence Orthology more info
negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
pituitary gland development	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular component movement	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
regulation of extracellular matrix disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
response to antibiotic	IEA Inferred from Electronic Annotation more info
response to antibiotic	ISO Inferred from Sequence Orthology more info
response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
response to laminar fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to wounding	IEP Inferred from Expression Pattern more info	PubMed
transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info
transcription factor complex	IEA Inferred from Electronic Annotation more info
transcription factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein C-ets-1

Names: protein C-ets-1; p54; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012555.2 → NP_036687.1 protein C-ets-1

Status: VALIDATED

Source sequence(s)

AABR06053999, BC101927, L20681

UniProtKB/Swiss-Prot

P41156

Related

ENSRNOP00000011925, ENSRNOT00000011925

Conserved Domains (2) summary

pfam00178
Location:334 – 417
Blast Score: 430

Ets; Ets-domain

cd08542
Location:51 – 138
Blast Score: 501

SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005107.3 Reference Rnor_5.0 Primary Assembly

Range

33858347..33921593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000076.1 Alternate Rn_Celera

Range

32555513..32617691

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AABR06053998.1 (60018..66947)	None
genomic	AABR06053999.1	None
genomic	AAHX01053967.1 (4907..12263)	None
genomic	AAHX01053968.1	None
genomic	AAHX01053969.1	None
genomic	AAHX01053970.1 (60236..69443)	None
genomic	CH474007.2	EDL83287.1
genomic	L20682.1	None
mRNA	BC101927.1	AAI01928.1
mRNA	L20681.1	AAA21093.1