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Ets1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24356, updated on 12-Apr-2014
Official Symbol
Ets1provided by RGD
Official Full Name
v-ets avian erythroblastosis virus E26 oncogene homolog 1provided by RGD
Primary source
RGD:2583
See related
Ensembl:ENSRNOG00000008941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Tpl1; Ets-1; Etsoncb
Summary
activates transcription of cyclin-dependent kinase inhibitor p21WAF1/Cip1; plays a role in inhibition of apoptosis [RGD, Feb 2006]
Location :
8q21
Sequence :
Chromosome: 8; NC_005107.3 (33798598..33921593)
See Ets1 in MapViewer

Chromosome 8 - NC_005107.3Genomic Context describing neighboring genes Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC102552161 Neighboring gene uncharacterized LOC102552230 Neighboring gene uncharacterized LOC102552355 Neighboring gene urinary protein 3-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
PML body organization IEA
Inferred from Electronic Annotation
more info
 
PML body organization ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic nuclear changes IEA
Inferred from Electronic Annotation
more info
 
apoptotic nuclear changes ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell motility IEA
Inferred from Electronic Annotation
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
estrous cycle phase IEP
Inferred from Expression Pattern
more info
PubMed 
execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular component movement ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to laminar fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein C-ets-1
Names
protein C-ets-1
p54
v-ets erythroblastosis virus E26 oncogene homolog 1
Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012555.2NP_036687.1  protein C-ets-1

    See proteins identical to NP_036687.1

    Status: VALIDATED

    Source sequence(s)
    AABR06053999, BC101927, L20681
    UniProtKB/Swiss-Prot
    P41156
    Related
    ENSRNOP00000011925, ENSRNOT00000011925
    Conserved Domains (2) summary
    cd08542
    Location:51138
    Blast Score: 526
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    pfam00178
    Location:334417
    Blast Score: 443
    Ets; Ets-domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005107.3

    Range
    33798598..33921593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242750.1XP_006242812.1  

    See proteins identical to XP_006242812.1

    Conserved Domains (2) summary
    cd08542
    Location:95182
    Blast Score: 529
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    pfam00178
    Location:378461
    Blast Score: 446
    Ets; Ets-domain
  2. XM_006242751.1XP_006242813.1  

    See proteins identical to XP_006242813.1

    Conserved Domains (2) summary
    cd08542
    Location:95182
    Blast Score: 529
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    pfam00178
    Location:378461
    Blast Score: 446
    Ets; Ets-domain
  3. XM_006242752.1XP_006242814.1  

    See proteins identical to XP_006242814.1

    Conserved Domains (2) summary
    cd08542
    Location:51138
    Blast Score: 521
    SAM_PNT-ETS-1; Sterile alpha motif (SAM)/Pointed domain of ETS-1
    pfam00178
    Location:247330
    Blast Score: 441
    Ets; Ets-domain

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    32555513..32617691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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