Format

Send to:

Choose Destination

Erbb2 erb-b2 receptor tyrosine kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24337, updated on 29-May-2016
Official Symbol
Erbb2provided by RGD
Official Full Name
erb-b2 receptor tyrosine kinase 2provided by RGD
Primary source
RGD:2561
See related
Ensembl:ENSRNOG00000006450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in cell proliferation and differentiation [RGD, Feb 2006]
Orthologs
Location:
10q32.1
Exon count:
27
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86367596..86391728)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (86163531..86187663)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene post-GPI attachment to proteins 3 Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase I core binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase I core binding ISS
Inferred from Sequence or Structural Similarity
more info
 
glycoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to growth factor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor signaling protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
estrous cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
liver development IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
myelination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase I promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase I promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase III promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase III promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule-based process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
signal transduction by protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tongue development IEP
Inferred from Expression Pattern
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lateral loop IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
C-erbB-2
NEU proto-oncogene
epidermal growth factor receptor-related protein
p185erbB2
p185neu
proto-oncogene NEU
proto-oncogene c-ErbB-2
v-erb-b2 avian erythroblastic leukemia viral oncogene 2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_058699.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017003.2NP_058699.2  receptor tyrosine-protein kinase erbB-2 precursor

    See identical proteins and their annotated locations for NP_058699.2

    Status: VALIDATED

    Source sequence(s)
    AY116182
    UniProtKB/TrEMBL
    Q8K3F9
    Related
    ENSRNOP00000040591, ENSRNOT00000049070
    Conserved Domains (7) summary
    cd12094
    Location:645688
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    cd00064
    Location:239284
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:193347
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:55177
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:724980
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14843
    Location:514647
    GF_recep_IV; Growth factor receptor domain IV
    cd05109
    Location:716994
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    86367596..86391728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    82158844..82182518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)