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Fbxl5 F-box and leucine-rich repeat protein 5 [ Mus musculus (house mouse) ]

Gene ID: 242960, updated on 28-May-2016
Official Symbol
Fbxl5provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 5provided by MGI
Primary source
MGI:MGI:2152883
See related
Ensembl:ENSMUSG00000039753 Vega:OTTMUSG00000029016; Vega:OTTMUSG00000053749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbl4; Fir4
Orthologs
Location:
5; 5 B3
Exon count:
11
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (43744618..43782149, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (44135857..44173388, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 7 Neighboring gene predicted gene 15866 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene CD38 antigen

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
iron ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159963.1NP_001153435.1  F-box/LRR-repeat protein 5 isoform A

    See identical proteins and their annotated locations for NP_001153435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AK150664, AK159744, BY245949
    Consensus CDS
    CCDS51489.1
    UniProtKB/Swiss-Prot
    Q8C2S5
    Related
    ENSMUSP00000045792, OTTMUSP00000036968, ENSMUST00000047857, OTTMUST00000071988
    Conserved Domains (4) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    pfam12937
    Location:205249
    F-box-like; F-box-like
    sd00034
    Location:358384
    LRR_AMN1; leucine-rich repeat [structural motif]
  2. NM_178729.4NP_848844.1  F-box/LRR-repeat protein 5 isoform B

    See identical proteins and their annotated locations for NP_848844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AK041497, BC113798, BY245949
    Consensus CDS
    CCDS19263.1
    UniProtKB/Swiss-Prot
    Q8C2S5
    Related
    ENSMUSP00000084733, OTTMUSP00000036972, ENSMUST00000087465, OTTMUST00000071992
    Conserved Domains (5) summary
    cd09293
    Location:340404
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:7160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    pfam12937
    Location:205249
    F-box-like; F-box-like
    pfam13855
    Location:355393
    LRR_8; Leucine rich repeat
    sd00034
    Location:333357
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    43744618..43782149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    41173924..41211343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)