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Chrm3 cholinergic receptor, muscarinic 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24260, updated on 26-May-2016
Official Symbol
Chrm3provided by RGD
Official Full Name
cholinergic receptor, muscarinic 3provided by RGD
Primary source
RGD:2343
See related
Ensembl:ENSRNOG00000049410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
G-protein coupled receptor, muscarinic receeptor subtype that mediates cholinergic-induced contraction in most smooth muscle [RGD, Feb 2006]
Orthologs
Location:
17q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (63990599..64463222, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (65753665..66217211, complement)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548683 Neighboring gene zinc finger, MYND-type containing 11 Neighboring gene similar to TGF beta-inducible nuclear protein 1 (CDK105 protein) Neighboring gene uncharacterized LOC102548033

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G-protein coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled acetylcholine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled acetylcholine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
digestion ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of vascular smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
muscarinic acetylcholine receptor M3
Names
cholinergic receptor, muscarinic 3, cardiac

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012527.2NP_036659.2  muscarinic acetylcholine receptor M3

    See identical proteins and their annotated locations for NP_036659.2

    Status: VALIDATED

    Source sequence(s)
    AABR07028303, AABR07028305, AABR07028310, AABR07028312, AABR07072561
    UniProtKB/Swiss-Prot
    P08483
    Conserved Domains (2) summary
    pfam00001
    Location:90277
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:76208
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    63990599..64463222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771690.1XP_008769912.1  

    See identical proteins and their annotated locations for XP_008769912.1

    UniProtKB/Swiss-Prot
    P08483
    Related
    ENSRNOP00000067435, ENSRNOT00000075651
    Conserved Domains (2) summary
    pfam00001
    Location:90277
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:76208
    7tm_4; Olfactory receptor

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    60109356..60562246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)