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Camk2b calcium/calmodulin-dependent protein kinase II beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 24245, updated on 8-May-2016
Official Symbol
Camk2bprovided by RGD
Official Full Name
calcium/calmodulin-dependent protein kinase II betaprovided by RGD
Primary source
RGD:2262
See related
Ensembl:ENSRNOG00000052080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ck2b
Summary
beta subunit of calcium/calmodulin-dependent protein kinase II; may be involved in retinal development [RGD, Feb 2006]
Orthologs
Location:
14q21
Exon count:
24
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86208876..86297751, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (86893062..86982256, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene glucokinase Neighboring gene segmentation polarity homeobox protein engrailed-like Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene NudC domain containing 3 Neighboring gene similar to ribosomal protein L13A Neighboring gene NPC1 like intracellular cholesterol transporter 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
phospholipase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
activation of meiosis involved in egg activation ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cell projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
inhibitory G-protein coupled receptor phosphorylation ISO
Inferred from Sequence Orthology
more info
 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
neuronal postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
spindle midzone ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
Ca++/calmodulin-dependent protein kinase II beta subunit
caM kinase II subunit beta
caM-kinase II beta chain
caMK-II subunit beta
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
calcium/calmodulin-dependent protein kinase type II beta chain
NP_001035813.1
NP_001035815.1
NP_068507.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042354.1NP_001035813.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001035813.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AABR03091248, CB616255, CO395982, CO406099, X83375
    UniProtKB/TrEMBL
    F1LNI8, Q63094
    Related
    ENSRNOP00000068938, ENSRNOT00000081607
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:457584
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  2. NM_001042356.1NP_001035815.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    See identical proteins and their annotated locations for NP_001035815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate, in-frame exons in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AABR03091248, CB616255, CB692429, CB728582, M16112
    UniProtKB/Swiss-Prot
    P08413
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  3. NM_021739.2NP_068507.2  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_068507.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AABR03091248, CB616255, CO395982, M16112
    UniProtKB/Swiss-Prot
    P08413
    UniProtKB/TrEMBL
    G3V9G3
    Related
    ENSRNOP00000073205, ENSRNOT00000085265
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    86208876..86297751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251174.2XP_006251236.1  

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:495622
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  2. XM_006251172.2XP_006251234.1  

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:510637
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  3. XM_006251171.2XP_006251233.1  

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:519646
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  4. XM_006251170.2XP_006251232.1  

    See identical proteins and their annotated locations for XP_006251232.1

    UniProtKB/TrEMBL
    F1LUE2
    Related
    ENSRNOP00000058882, ENSRNOT00000067162
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  5. XM_006251176.2XP_006251238.1  

    See identical proteins and their annotated locations for XP_006251238.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
  6. XM_006251177.2XP_006251239.1  

    See identical proteins and their annotated locations for XP_006251239.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II Association
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    79728956..79817594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)