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Bcl2 B-cell CLL/lymphoma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24224, updated on 17-May-2016
Official Symbol
Bcl2provided by RGD
Official Full Name
B-cell CLL/lymphoma 2provided by RGD
Primary source
RGD:2199
See related
Ensembl:ENSRNOG00000002791
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Bcl-2
Summary
an anti-apoptotic protein; involved in inhibiting cell death in many different cell types [RGD, Feb 2006]
Orthologs
Location:
13p13
Exon count:
2
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (26605426..26769374, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (31758213..31920775, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene PH domain and leucine rich repeat protein phosphatase 1 Neighboring gene uncharacterized LOC103691610 Neighboring gene serpin B12-like Neighboring gene uncharacterized LOC102552849 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4 homolog B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
    AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
  • ATM, organism-specific biosystem (from WikiPathways)
    ATM, organism-specific biosystem
    ATM
  • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
    Activation of BAD and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
    Activation of BH3-only proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Estrogen signalling, organism-specific biosystem (from WikiPathways)
    Estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
  • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
    FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammasomes, organism-specific biosystem (from REACTOME)
    Inflammasomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
    The NLRP1 inflammasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
BH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
channel activity IEA
Inferred from Electronic Annotation
more info
 
channel activity ISO
Inferred from Sequence Orthology
more info
 
channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
B cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
B cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
CD8-positive, alpha-beta T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
CD8-positive, alpha-beta T cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
T cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
actin filament organization ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
axon regeneration IEA
Inferred from Electronic Annotation
more info
 
axon regeneration ISO
Inferred from Sequence Orthology
more info
 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell aging ISO
Inferred from Sequence Orthology
more info
 
cell growth IEA
Inferred from Electronic Annotation
more info
 
cell growth ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
cochlear nucleus development IEA
Inferred from Electronic Annotation
more info
 
cochlear nucleus development ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
developmental growth ISO
Inferred from Sequence Orthology
more info
 
developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
digestive tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
ear development ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
glial cell apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
glomerulus development IEA
Inferred from Electronic Annotation
more info
 
glomerulus development ISO
Inferred from Sequence Orthology
more info
 
growth ISO
Inferred from Sequence Orthology
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
immune system development ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
leukocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
lymphocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
lymphoid progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lymphoid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
melanin metabolic process IEA
Inferred from Electronic Annotation
more info
 
melanin metabolic process ISO
Inferred from Sequence Orthology
more info
 
melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
mesenchymal cell development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell development ISO
Inferred from Sequence Orthology
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
metanephros development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of anoikis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion transport into cytosol IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular pH reduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular pH reduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of retinal cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of retinal cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
oligodendrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
oocyte development IEA
Inferred from Electronic Annotation
more info
 
oocyte development ISO
Inferred from Sequence Orthology
more info
 
organ growth IEA
Inferred from Electronic Annotation
more info
 
organ growth ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
ossification ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
pigment granule organization IEA
Inferred from Electronic Annotation
more info
 
pigment granule organization ISO
Inferred from Sequence Orthology
more info
 
pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of melanocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of melanocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle fiber development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane permeability ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of nitrogen utilization IEA
Inferred from Electronic Annotation
more info
 
regulation of nitrogen utilization ISO
Inferred from Sequence Orthology
more info
 
regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
regulation of protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein stability IEA
Inferred from Electronic Annotation
more info
 
regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
regulation of transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
renal system process IEA
Inferred from Electronic Annotation
more info
 
renal system process ISO
Inferred from Sequence Orthology
more info
 
response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to UV-B IEA
Inferred from Electronic Annotation
more info
 
response to UV-B ISO
Inferred from Sequence Orthology
more info
 
response to aluminum ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to iron ion IEA
Inferred from Electronic Annotation
more info
 
response to iron ion ISO
Inferred from Sequence Orthology
more info
 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
response to ischemia ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
spleen development ISO
Inferred from Sequence Orthology
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
pore complex IEA
Inferred from Electronic Annotation
more info
 
pore complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
apoptosis regulator Bcl-2
Names
B cell lymphoma 2 associated oncogene
B-cell leukemia/lymphoma 2
Bcl2-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016993.1NP_058689.1  apoptosis regulator Bcl-2

    See identical proteins and their annotated locations for NP_058689.1

    Status: PROVISIONAL

    Source sequence(s)
    L14680
    UniProtKB/Swiss-Prot
    P49950
    Related
    ENSRNOP00000003768, ENSRNOT00000003768
    Conserved Domains (3) summary
    cd06845
    Location:78198
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    pfam02180
    Location:733
    BH4; Bcl-2 homology region 4
    TIGR00865
    Location:11236
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    26605426..26769374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    22550362..22711143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)